{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:27:34Z","timestamp":1792722454464,"version":"4.5.0"},"reference-count":89,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In this study, we investigated how different categories of prenatal malaria exposure (PME) influence levels of maternal antibodies in cord blood samples and the subsequent risk of malaria in early childhood in a birth cohort study (\n            <jats:italic>N<\/jats:italic>\n            = 661) nested within the COSMIC clinical trial (NCT01941264) in Burkina Faso.\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            infections during pregnancy and infants\u2019 clinical malaria episodes detected during the first year of life were recorded. The levels of maternal IgG and IgG\n            <jats:sub>1-4<\/jats:sub>\n            to 15\n            <jats:italic>P<\/jats:italic>\n            .\n            <jats:italic>falciparum<\/jats:italic>\n            antigens were measured in cord blood by quantitative suspension array technology. Results showed a significant variation in the magnitude of maternal antibody levels in cord blood, depending on the PME category, with past placental malaria (PM) more frequently associated with significant increases of IgG and\/or subclass levels across three groups of antigens defined as pre-erythrocytic, erythrocytic, and markers of PM, as compared to those from the cord of non-exposed control infants. High levels of antibodies to certain erythrocytic antigens (i.e., IgG to EBA140 and EBA175, IgG1 to EBA175 and MSP1\n            <jats:sub>42<\/jats:sub>\n            , and IgG3 to EBA140 and MSP5) were independent predictors of protection from clinical malaria during the first year of life. By contrast, high levels of IgG, IgG1, and IgG2 to the VAR2CSA DBL1-2 and IgG4 to DBL3-4 were significantly associated with an increased risk of clinical malaria. These findings indicate that PME categories have different effects on the levels of maternal-derived antibodies to malaria antigens in children at birth, and this might drive heterogeneity to clinical malaria susceptibility in early childhood.\n          <\/jats:p>","DOI":"10.1128\/iai.00268-23","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:04:19Z","timestamp":1695819859000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso"],"prefix":"10.1128","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-077X","authenticated-orcid":false,"given":"Hamtandi Magloire","family":"Natama","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Sant\u00e9, Direction R\u00e9gionale du Centre-Ouest , Nanoro, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Moncunill","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC) , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vidal","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toussaint","family":"Rouamba","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Sant\u00e9, Direction R\u00e9gionale du Centre-Ouest , Nanoro, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Santano","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC) , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Rovira-Vallbona","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic \u2013 Universitat de Barcelona , Barcelona, Spain"},{"name":"CIBER de Epidemiologia y Salud P\u00fablica (CIBERESP) , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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