{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:25:54Z","timestamp":1791199554314,"version":"4.2.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with\n            <jats:italic>Tropheryma whipplei<\/jats:italic>\n            , its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of\n            <jats:italic>T. whipplei<\/jats:italic>\n            suggests a protective role for innate immunity.\n          <\/jats:p>","DOI":"10.1128\/iai.00283-06","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T00:24:50Z","timestamp":1153527890000},"page":"4915-4917","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Murine Model of Infection by\n            <i>Tropheryma whipplei<\/i>"],"prefix":"10.1128","volume":"74","author":[{"given":"Se\u0301verine","family":"Genot","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Stein","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Lepidi","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ihrig","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&amp;M University, College Station, Texas 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mege","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12597-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.005"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90092-1"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/491745"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4575"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.561-583.2001"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00126-6"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36583"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247462"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12274-X"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420903"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1474603"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.00320030099012"},{"key":"e_1_3_1_15_2","first-page":"1070","volume":"20","year":"1993","unstructured":"Rouillon, A., C. J. Menkes, J. C. Gerster, I. Perez-Sawka, and M. Forest. 1993. Sarcoid-like forms of Whipple's disease. Report of 2 cases. J. Rheumatol.20:1070-1072.","journal-title":"J. Rheumatol."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420100103032"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00283-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00283-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:43:00Z","timestamp":1646462580000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00283-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1128\/IAI.00283-06"],"URL":"https:\/\/doi.org\/10.1128\/iai.00283-06","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2006-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}