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SUMOylation, a reversible post-translational modification process, plays an important role in biological life activities. In addition to being critical to host cell metabolism and survival, SUMOylation also regulates gene expression and cell signal transmission. Moreover, SUMOylation in eukaryotic cells can be used by a variety of bacterial pathogens to advance bacterial invasion. In this minireview, we focused on the role and mechanism of host SUMOylation in the pathogenesis of six important clinical bacterial pathogens (\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    ,\n                    <jats:italic>Shigella flexneri<\/jats:italic>\n                    ,\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium\n                    <jats:italic>, Klebsiella pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ). Taken together, this review provided new insights for understanding the unique pathogen-host interaction based on host SUMOylation and provided a novel perspective on the development of new strategies to combat bacterial infections in the future.\n                  <\/jats:p>","DOI":"10.1128\/iai.00283-23","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T14:37:41Z","timestamp":1695134261000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Roles of host SUMOylation in bacterial pathogenesis"],"prefix":"10.1128","volume":"91","author":[{"given":"Xin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University , Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of 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