{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:31:15Z","timestamp":1790015475846,"version":"4.0.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The host deploys a subset of immune responses to expel helminths, which differs depending on the nature of the helminth.<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Strongyloides venezuelensis<\/jats:named-content>, a counterpart of the human pathogen<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. stercoralis<\/jats:named-content>, naturally infects rodents and has been used as an experimental model. Here we show that induction of immunoglobulin G (IgG) and IgE is a prerequisite for rapid expulsion of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>during a primary infection. Activation-induced cytidine deaminase-deficient (AID<jats:sup>\u2212\/\u2212<\/jats:sup>) mice, which lack the ability to switch IgM to other isotypes, normally developed T-helper 2 (Th2) cells and intestinal mastocytosis after infection with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>. Although AID<jats:sup>\u2212\/\u2212<\/jats:sup>mice expelled<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Nippostrongylus brasiliensis<\/jats:named-content>normally, they required a much longer period to expel<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>than wild-type (WT) mice. Adoptive transfers of immune sera from<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>-infected but not<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. brasiliensis<\/jats:named-content>-infected mice restored the ability of AID<jats:sup>\u2212\/\u2212<\/jats:sup>mice to promptly expel<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>. Immune serum-derived IgG and IgE induced worm expulsion via Fc \u03b3 receptor III (Fc\u03b3RIII) and Fc \u03b5 receptor I (Fc\u03b5RI), respectively, and a mixture of IgG and IgE showed collaborative effects. Whereas Fc\u03b3RIII<jats:sup>\u2212\/\u2212<\/jats:sup>mice or Fc\u03b5RI\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup>mice normally could expel<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>, Fc\u03b3RIII<jats:sup>\u2212\/\u2212<\/jats:sup>mice, when their IgE was neutralized by anti-IgE, or Fc\u03b5RI\u03b1<jats:sup>\u2212\/\u2212<\/jats:sup>mice, when their IgG binding to Fc\u03b3RIII was blocked by anti-Fc\u03b3RIII, showed a markedly reduced ability to expel<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>. These data reveal that IgG and IgE play redundant roles but act in concert to accelerate<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>expulsion. Mast cell-deficient mice, even those equipped with immune serum-derived IgG or IgE, failed to expel<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. venezuelensis<\/jats:named-content>promptly, suggesting that mast cells are cellular targets of IgG and IgE.<\/jats:p>","DOI":"10.1128\/iai.00285-13","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T04:03:46Z","timestamp":1367294626000},"page":"2518-2527","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection"],"prefix":"10.1128","volume":"81","author":[{"given":"Makoto","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koubun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00192.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102057"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902879"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4049\/jimmunol.158.1.294","article-title":"Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni","volume":"158","author":"King CL","year":"1997","unstructured":"KingCLXianliJMalhotraILiuSMahmoudAAOettgenHC. 1997. 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