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The mechanism of dendritic cell regulation in<jats:italic>Helicobacter<\/jats:italic>-induced gastritis is poorly understood. These studies characterized DC isolated from the lamina propria of<jats:italic>Helicobacter<\/jats:italic>-infected mice and analyzed innate and adaptive immune responses elicited by<jats:italic>Helicobacter<\/jats:italic>antigen (Ag)-pulsed DC. The presence of DC was elevated in the gastric lamina propria infiltrate of infected mice in comparison with controls. After treatment with<jats:italic>Helicobacter felis<\/jats:italic>Ag, DC were polarized to secrete interleukin-6 as the dominant cytokine. In the presence of DC and<jats:italic>Helicobacter<\/jats:italic>Ag, responder allogeneic T cells in culture exhibited limited cell division. We suggest that the response of DC and T cells to<jats:italic>Helicobacter<\/jats:italic>Ag is critical to the chronic persistence of<jats:italic>Helicobacter<\/jats:italic>-induced gastritis.<\/jats:p>","DOI":"10.1128\/iai.00289-06","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T00:24:50Z","timestamp":1153527890000},"page":"4624-4633","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Regulation of Murine Dendritic Cell Immune Responses by<i>Helicobacter felis<\/i>Antigen"],"prefix":"10.1128","volume":"74","author":[{"given":"Maureen L.","family":"Drakes","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Czinn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1635"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_3_2_5_2","first-page":"1377","volume":"152","year":"1998","unstructured":"Berg, D. 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