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Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W, and Y. More recently two protein-based vaccines, Bexsero and Trumenba, against meningococcal serogroup B strains have been licensed; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface-exposed lipoprotein that binds the negative complement regulator complement factor H (CFH), thereby inhibiting the alternative pathway of complement activation. Recent analysis of available genomes has indicated that some commensal\n            <jats:named-content content-type=\"genus-species\">Neisseria<\/jats:named-content>\n            species also contain genes that potentially encode fHbp, although the functions of these genes and how immunization with fHbp-containing vaccines could affect the commensal flora have yet to be established. Here, we show that the commensal species\n            <jats:named-content content-type=\"genus-species\">Neisseria cinerea<\/jats:named-content>\n            expresses functional fHbp on its surface and that it is responsible for recruitment of CFH by the bacterium.\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            fHbp binds CFH with affinity similar to that of meningococcal fHbp and promotes survival of\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            in human serum. We examined the potential impact of fHbp-containing vaccines on\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            . We found that immunization with Bexsero elicits serum bactericidal activity against\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            , which is primarily directed against fHbp. The shared function of fHbp in\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            and cross-reactive responses elicited by Bexsero suggest that the introduction of fHbp-containing vaccines has the potential to affect carriage of\n            <jats:named-content content-type=\"genus-species\">N. cinerea<\/jats:named-content>\n            and other commensal species.\n          <\/jats:p>","DOI":"10.1128\/iai.00305-17","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:20:22Z","timestamp":1500942022000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines"],"prefix":"10.1128","volume":"85","author":[{"given":"Hayley","family":"Lavender","sequence":"first","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Poncin","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph M.","family":"Tang","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"doi-asserted-by":"publisher","key":"e_1_3_3_2_2","DOI":"10.1128\/jcm.26.5.896-900.1988"},{"doi-asserted-by":"publisher","key":"e_1_3_3_3_2","DOI":"10.1093\/oxfordjournals.molbev.a026162"},{"doi-asserted-by":"publisher","key":"e_1_3_3_4_2","DOI":"10.1016\/S0140-6736(07)61016-2"},{"doi-asserted-by":"publisher","key":"e_1_3_3_5_2","DOI":"10.1146\/annurev.me.34.020183.002005"},{"doi-asserted-by":"publisher","key":"e_1_3_3_6_2","DOI":"10.1093\/infdis\/137.2.112"},{"doi-asserted-by":"publisher","key":"e_1_3_3_7_2","DOI":"10.1186\/1471-2180-9-259"},{"doi-asserted-by":"publisher","key":"e_1_3_3_8_2","DOI":"10.1099\/mic.0.056077-0"},{"doi-asserted-by":"publisher","key":"e_1_3_3_9_2","DOI":"10.1016\/S0769-2609(86)80106-5"},{"doi-asserted-by":"publisher","key":"e_1_3_3_10_2","DOI":"10.1099\/mic.0.000086"},{"doi-asserted-by":"publisher","key":"e_1_3_3_11_2","DOI":"10.1093\/clinids\/7.4.504"},{"doi-asserted-by":"publisher","key":"e_1_3_3_12_2","DOI":"10.1097\/00006454-200004000-00015"},{"doi-asserted-by":"publisher","key":"e_1_3_3_13_2","DOI":"10.1016\/S0140-6736(02)08416-7"},{"doi-asserted-by":"publisher","key":"e_1_3_3_14_2","DOI":"10.3201\/eid1904.111799"},{"doi-asserted-by":"publisher","key":"e_1_3_3_15_2","DOI":"10.1016\/j.vaccine.2011.12.060"},{"doi-asserted-by":"publisher","key":"e_1_3_3_16_2","DOI":"10.1093\/aje\/kwm147"},{"doi-asserted-by":"publisher","key":"e_1_3_3_17_2","DOI":"10.1016\/S0140-6736(83)90340-9"},{"key":"e_1_3_3_18_2","first-page":"67","article-title":"Production, characterization and control of MenB-vaccine \u201cFolkehelsa\u201d: an outer membrane vesicle vaccine against group B meningococcal disease","volume":"14","author":"Fredriksen JH","year":"1991","unstructured":"Fredriksen JH Rosenqvist E Wedege E Bryn K Bjune G Fr\u00f8holm LO Lindbak AK M\u00f8gster B Namork E Rye U . 1991. 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