{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:17:09Z","timestamp":1793593029410,"version":"4.5.0"},"reference-count":80,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"DST | Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SER-1058-BIO"],"award-info":[{"award-number":["SER-1058-BIO"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","award":["FIG\/100702\/15"],"award-info":[{"award-number":["FIG\/100702\/15"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT-843-BIO"],"award-info":[{"award-number":["DBT-843-BIO"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DBT-JRF Fellowship"],"award-info":[{"award-number":["DBT-JRF Fellowship"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:p>The rising incidence of non-albicans<jats:italic>Candida<\/jats:italic>species globally, along with the emergence of drug resistance, is a cause for concern. This study investigated the protective efficacy of secreted aspartyl proteinase 2 (Sap2) in systemic<jats:named-content content-type=\"genus-species\">C. tropicalis<\/jats:named-content>infection. Vaccination with recombinant Sap2 (rSap2) protein from<jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>enhanced survival of mice compared to rSap2 vaccinations from<jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>(<jats:italic>P<\/jats:italic>\u2009=\u20090.<\/jats:p>","DOI":"10.1128\/iai.00312-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T14:27:19Z","timestamp":1594736839000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Vaccination with Secreted Aspartyl Proteinase 2 Protein from<i>Candida parapsilosis<\/i>Can Enhance Survival of Mice during<i>C. tropicalis<\/i>-Mediated Systemic Candidiasis"],"prefix":"10.1128","volume":"88","author":[{"given":"Manisha","family":"Shukla","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-3132","authenticated-orcid":false,"given":"Soma","family":"Rohatgi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.48.1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1313-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003550"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.07.025"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2015.29"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.010"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01927"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00278.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.08.012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.04.008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3156"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4161\/21505594.2014.983015"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00897"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.67.3.400-428.2003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.5.2725-2729.2002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00802.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.01.012"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01819.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.069"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx139"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2014.932253"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1997.tb01080.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00302-13"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00576.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000703"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2939"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2015.1125472"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046020"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/314643"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.154.10.5273","article-title":"Growth inhibition of Candida albicans hyphae by CD8+ lymphocytes","volume":"154","author":"Beno DW","year":"1995","unstructured":"Beno DW, St\u00f6ver AG, Mathews HL. 1995. Growth inhibition of Candida albicans hyphae by CD8+ lymphocytes. J Immunol 154:5273\u20135281.","journal-title":"J Immunol"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.1.194-202.1994"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.12.021"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005392"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.8.3399-3405.1997"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.7.2619-2624.1995"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1086\/509891"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt.09.76"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.9.5273-5279.2003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01590.x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.71.6.3227-3234.2003"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1086\/314546"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2758-2765.2005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2018.07.005"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01072-07"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00484-19"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.05.030"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01349"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.3.589"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201514"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx255"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.09.016"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2010.00620.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601572"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1370529"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00265-13"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.12.038"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100034"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/bedab014-d393-4fad-aa07-0df1efb59038"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00786.x"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.27714"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1184385"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00807-16"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02789-14"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00469-16"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00724-15"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05498.x"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03676.x"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025909"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701883508"},{"key":"e_1_3_3_72_2","first-page":"63","article-title":"The antigenic fractions of Candida albicans: subcellular components, the whole cell, cell wall, and cell membrane","volume":"34","author":"Ibrahim EM","year":"2006","unstructured":"Ibrahim EM, Mosaad AA, Hassan HY. 2006. The antigenic fractions of Candida albicans: subcellular components, the whole cell, cell wall, and cell membrane. Zagazig Vet J 34:63\u201371.","journal-title":"Zagazig Vet J"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00573-10"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/npjbiofilms.2015.12"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.1.108"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2017.09.003"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00573-13"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00130"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747019"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032621"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00312-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00312-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:49:00Z","timestamp":1696402140000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00312-20"}},"subtitle":[],"editor":[{"given":"Mairi C.","family":"Noverr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":80,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,9,18]]}},"alternative-id":["10.1128\/IAI.00312-20"],"URL":"https:\/\/doi.org\/10.1128\/iai.00312-20","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00312-20"}}