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We used bioluminescent strains of\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            to monitor the formation of infection foci during the first 24 h of hematogenous bacterial dissemination. Clinically derived EDIN-expressing\n            <jats:italic>S. aureus<\/jats:italic>\n            strains S25 and Xen36 produced many disseminated foci. EDIN had no detectable impact on infection foci in terms of histopathology or the intensity of emitted light. Moreover, EDIN did not modify the course of bacterial clearance from the bloodstream. In contrast, we show that EDIN expression promotes a 5-fold increase in the number of infection foci produced by Xen36. This virulence activity of EDIN requires RhoA ADP-ribosyltranferase activity. These results suggest that EDIN is a risk factor for\n            <jats:italic>S. aureus<\/jats:italic>\n            dissemination through the vasculature by virtue of its ability to promote the formation of infection foci in deep-seated tissues.\n          <\/jats:p>","DOI":"10.1128\/iai.00319-10","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T03:25:05Z","timestamp":1274153105000},"page":"3404-3411","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["The\n            <i>Staphylococcus aureus<\/i>\n            Epidermal Cell Differentiation Inhibitor Toxin Promotes Formation of Infection Foci in a Mouse Model of Bacteremia"],"prefix":"10.1128","volume":"78","author":[{"given":"Patrick","family":"Munro","sequence":"first","affiliation":[{"name":"INSERM, U895, C3M, Toxines Microbiennes dans la Relation Ho\u0302te Pathoge\u0300nes, Universite\u0301 de Nice-Sophia-Antipolis, UFR Me\u0301decine, IFR50, Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Benchetrit","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, Ho\u0302pital Pasteur, CHU de Nice, 30 Avenue de la Voie-Romaine, BP 69, Nice 06002, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries-Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris 75015, France"},{"name":"INRA, USC2020, Paris 75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Stefani","sequence":"additional","affiliation":[{"name":"INSERM, U895, C3M, Toxines Microbiennes dans la Relation Ho\u0302te Pathoge\u0300nes, Universite\u0301 de Nice-Sophia-Antipolis, UFR Me\u0301decine, IFR50, Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u0301","family":"Cle\u0301ment","sequence":"additional","affiliation":[{"name":"INSERM, U895, C3M, Toxines Microbiennes dans la Relation Ho\u0302te Pathoge\u0300nes, Universite\u0301 de Nice-Sophia-Antipolis, UFR Me\u0301decine, IFR50, Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Franc\u0327ois","family":"Michiels","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, Ho\u0302pital Pasteur, CHU de Nice, 30 Avenue de la Voie-Romaine, BP 69, Nice 06002, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luce","family":"Landraud","sequence":"additional","affiliation":[{"name":"INSERM, U895, C3M, Toxines Microbiennes dans la Relation Ho\u0302te Pathoge\u0300nes, Universite\u0301 de Nice-Sophia-Antipolis, UFR Me\u0301decine, IFR50, Nice 06204, France"},{"name":"Laboratoire de Bacte\u0301riologie, CHU de Nice, Ho\u0302pital l'Archet, Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dussurget","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 des Interactions Bacte\u0301ries-Cellules, Paris F-75015, France"},{"name":"INSERM, U604, Paris 75015, France"},{"name":"INRA, USC2020, Paris 75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Lemichez","sequence":"additional","affiliation":[{"name":"INSERM, U895, C3M, Toxines Microbiennes dans la Relation Ho\u0302te Pathoge\u0300nes, Universite\u0301 de Nice-Sophia-Antipolis, UFR Me\u0301decine, IFR50, Nice 06204, France"},{"name":"Laboratoire de Bacte\u0301riologie, CHU de Nice, Ho\u0302pital l'Archet, Nice 06204, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1","volume":"152","year":"2004","unstructured":"Aktories, K., C. 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