{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:47:28Z","timestamp":1783594048158,"version":"3.55.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01AI121989"],"award-info":[{"award-number":["R01AI121989"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Chlamydiae colonize the gastrointestinal tracts of both animals and humans. However, their medical significance remains unknown. We have previously shown that wild-type\n            <jats:named-content content-type=\"genus-species\">Chlamydia muridarum<\/jats:named-content>\n            spreads to and establishes stable colonization of the gastrointestinal tract following intravaginal inoculation. In the present study, we found that\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            with mutations in chromosomal genes\n            <jats:italic>tc0237<\/jats:italic>\n            and\/or\n            <jats:italic>tc0668<\/jats:italic>\n            was defective in spreading to the mouse gastrointestinal tract, which correlated with its attenuated pathogenicity in the upper genital tract. This correlation was more consistent than that of chlamydial pathogenicity with ascending infection in the genital tract, since attenuated\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            spread significantly less to the gastrointestinal tract but maintained robust ascending infection of the upper genital tract. Transcervical inoculation further confirmed the correlation between\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            spreading to the gastrointestinal tract and its pathogenicity in the upper genital tract. Finally, defective spreading of\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            mutants was due to their inability to colonize the gastrointestinal tract since intragastric inoculation did not rescue the mutants' colonization. Thus, promoting\n            <jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>\n            colonization of the gastrointestinal tract may represent a primary function of the TC0237 and TC0668 proteins. Correlation of chlamydial colonization of the gastrointestinal tract with chlamydial pathogenicity in the upper genital tract suggests a potential role for gastrointestinal chlamydiae in genital tract pathogenicity.\n          <\/jats:p>","DOI":"10.1128\/iai.00321-17","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:30:20Z","timestamp":1496709020000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Chlamydia muridarum with Mutations in Chromosomal Genes\n            <i>tc0237<\/i>\n            and\/or\n            <i>tc0668<\/i>\n            Is Deficient in Colonizing the Mouse Gastrointestinal Tract"],"prefix":"10.1128","volume":"85","author":[{"given":"Lili","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182519326"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.06.021"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000148299.14513.11"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.2094-2097.1994"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095076"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.74"},{"key":"e_1_3_3_9_2","first-page":"980","article-title":"Vaccines for Chlamydia trachomatis infections","volume":"3","author":"de la Maza LM","year":"2002","unstructured":"de la Maza LM Peterson EM . 2002. 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