{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:24:01Z","timestamp":1777494241414,"version":"3.51.4"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In developing countries, one-third of reactive arthritis (ReA) cases are associated with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>enterocolitis; nevertheless, there is no animal model for studying this pathology. Here we induced a self-limiting<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella enterica<\/jats:named-content>serovar Enteritidis enterocolitis in mice to analyze the onset of ReA. BALB\/c mice received orally 20 \u03bcg of streptomycin 24 h before intragastric inoculation of a low dose (3 \u00d7 10<jats:sup>3<\/jats:sup>to 4 \u00d7 10<jats:sup>3<\/jats:sup>CFU) of<jats:italic>S<\/jats:italic>. Enteritidis. In response to<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>infection, a 30-fold increase in the expression of interleukin-17 (IL-17), measured by quantitative PCR, was observed in mesenteric lymph nodes 5 days postinfection. At this time synovitis was already evident, and concomitantly, a significant increase in joint tumor necrosis factor alpha (TNF-\u03b1) was detected by enzyme-linked immunosorbent assay (ELISA). The early development of joint lesions was accompanied by an increased expression of IL-17 in inguinal and popliteal lymph nodes. Infection with 10<jats:sup>7<\/jats:sup>CFU of an isogenic \u0394<jats:italic>invG<\/jats:italic>mutant bearing a defective type III secretion system of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>encoded in the pathogenicity island 1 apparatus (TTSS-1) induced enterocolitis histologically similar to that triggered by the wild-type strain. Interestingly, despite the higher infective dose used, the mutant did not trigger intestinal IL-17. Moreover, no synovitis was observed in mice suffering \u0394<jats:italic>invG<\/jats:italic>enterocolitis. Neutralization of IL-17 in mice infected with<jats:italic>S<\/jats:italic>. Enteritidis prevented both synovitis and the increment of TNF-\u03b1 in the joints, suggesting that IL-17 participates in the generation of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Salmonella<\/jats:named-content>-induced ReA through the induction of TNF-\u03b1 in the joints.<\/jats:p>","DOI":"10.1128\/iai.00324-12","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:47:04Z","timestamp":1334018824000},"page":"2231-2239","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Salmonella enterica Induces Joint Inflammation and Expression of Interleukin-17 in Draining Lymph Nodes Early after Onset of Enterocolitis in Mice"],"prefix":"10.1128","volume":"80","author":[{"given":"Mari\u00e1ngeles","family":"Noto Llana","sequence":"first","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n Hern\u00e1n","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Victoria","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Sonia","family":"Gartner","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica Nancy","family":"Giacomodonato","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Cristina","family":"Cerquetti","sequence":"additional","affiliation":[{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPAM-CONICET) and Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2039::AID-ANR3>3.0.CO;2-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4049\/jimmunol.156.2.794","article-title":"T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats","volume":"156","author":"Breban M","year":"1996","unstructured":"BrebanM. 1996. 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