{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:02:11Z","timestamp":1771480931665,"version":"3.50.1"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Chlamydia pneumoniae<\/jats:named-content>\n            is associated with chronic inflammatory lung diseases like bronchial asthma and chronic obstructive pulmonary disease. The existence of a causal link between allergic airway disease and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            is controversial. A mouse model was used to address the question of whether preceding\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            lung infection and recovery modifies the outcome of experimental allergic asthma after subsequent sensitization with house dust mite (HDM) allergen. After intranasal infection, BALB\/c mice suffered from pneumonia characterized by an increased clinical score, reduction of body weight, histopathology, and a bacterial load in the lungs. After 4 weeks, when infection had almost resolved clinically, HDM allergen sensitization was performed for another 4 weeks. Subsequently, mice were subjected to a methacholine hyperresponsiveness test and sacrificed for further analyses. As expected, after 8 weeks,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            -specific antibodies were detectable only in infected mice and the titer was significantly higher in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            \/HDM allergen-treated group than in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            \/NaCl group. Intriguingly, airway hyperresponsiveness and eosinophilia in bronchoalveolar lavage fluid were significantly lower in the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            \/HDM allergen-treated group than in the mock\/HDM allergen-treated group. We did observe a relationship between experimental asthma and chlamydial infection. Our results demonstrate an influence of sensitization to HDM allergen on the development of a humoral antibacterial response. However, our model demonstrates no increase in the severity of experimental asthma to HDM allergen as a physiological allergen after clinically resolved severe chlamydial lung infection. Our results rather suggest that allergic airway disease and concomitant cellular changes in mice are decreased following\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. pneumoniae<\/jats:named-content>\n            lung infection in this setting.\n          <\/jats:p>","DOI":"10.1128\/iai.00334-13","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T04:30:32Z","timestamp":1372739432000},"page":"3366-3374","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia pneumoniae in Mice"],"prefix":"10.1128","volume":"81","author":[{"given":"Pavel","family":"Dutow","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Lingner","sequence":"additional","affiliation":[{"name":"Pediatric Pneumonology and Allergology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Laudeley","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Glage","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz-Gerd","family":"Hoymann","sequence":"additional","affiliation":[{"name":"Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Biomedical 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Klos","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, 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