{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:57:37Z","timestamp":1791946657869,"version":"4.3.4"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001349","name":"MOH | National Medical Research Council","doi-asserted-by":"publisher","award":["R221-000-086-511"],"award-info":[{"award-number":["R221-000-086-511"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            , a major opportunistic fungal pathogen, is frequently found together with\n            <jats:named-content content-type=\"genus-species\">Streptococcus mutans<\/jats:named-content>\n            in dental biofilms associated with severe childhood caries (tooth decay), a prevalent pediatric oral disease. However, the impact of this cross-kingdom relationship on\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            remains largely uncharacterized. Here, we employed a novel quantitative proteomics approach in conjunction with transcriptomic profiling to unravel molecular pathways of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            when cocultured with\n            <jats:named-content content-type=\"genus-species\">S. mutans<\/jats:named-content>\n            in mixed biofilms.\n          <\/jats:p>","DOI":"10.1128\/iai.00339-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T12:33:06Z","timestamp":1565008386000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":114,"title":["Multi-omics Analyses Reveal Synergistic Carbohydrate Metabolism in Streptococcus mutans-Candida albicans Mixed-Species Biofilms"],"prefix":"10.1128","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3806-9807","authenticated-orcid":false,"given":"K.","family":"Ellepola","sequence":"first","affiliation":[{"name":"Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore"},{"name":"Center of Oral and Craniofacial Biology, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Truong","sequence":"additional","affiliation":[{"name":"Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics and Divisions of Pediatric Dentistry &amp; Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Lin","sequence":"additional","affiliation":[{"name":"Protein and Proteomic Centre, Department of Biological Sciences, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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