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The bacterium\u2019s impressive ability to adapt to changing environments and conditions requires the rapid sensing of environmental cues and the coordinated response of gene products that enable bacterial growth and survival. Two-component signaling systems (TCSs) have been long recognized for their ability to detect environmental stimuli and transmit those signals into transcriptional responses; however, often the precise nature of the stimulus triggering TCS responses can be challenging to define.\n              <jats:italic>L. monocytogenes<\/jats:italic>\n              has up to 16 TCSs that have been recognized based on homology and included in this list are several whose functions remain poorly described. This review highlights the current understanding of the breadth and scope of\n              <jats:italic>L. monocytogenes<\/jats:italic>\n              TCS as relates to stress resistance and pathogenesis. Precise signals still often remain elusive, but the gene networks associated with TCSs are providing clues into possible functions.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/iai.00345-23","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T13:11:29Z","timestamp":1709557889000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Revisiting old friends: updates on the role of two-component signaling systems in\n            <i>Listeria monocytogenes<\/i>\n            survival and pathogenesis"],"prefix":"10.1128","volume":"92","author":[{"given":"Xiomarie","family":"Alejandro-Navarreto","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-3978","authenticated-orcid":true,"given":"Nancy E.","family":"Freitag","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA"},{"name":"Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2018.02.006"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2171"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13367"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.584-640.2001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2005.02559.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.2.894-904.2005"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.02.028"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.710085"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2015.1965"},{"key":"e_1_3_1_11_2","first-page":"543","article-title":"Economic burden of major foodborne illnesses acquired in the United States","volume":"17","author":"Hoffmann S","year":"2015","unstructured":"Hoffmann S, Maculloch B, Batz M. 2015. 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