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It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. trachomatis<\/jats:named-content>occurring each year. Animal models are indispensable for the study of<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. trachomatis<\/jats:named-content>infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. trachomatis<\/jats:named-content>will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.<\/jats:p>","DOI":"10.1128\/iai.00357-13","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:37:28Z","timestamp":1373330248000},"page":"3060-3067","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Animal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis"],"prefix":"10.1128","volume":"81","author":[{"given":"Evelien","family":"De Clercq","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Kalmar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Vanrompay","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"2008","volume-title":"Global incidence and prevalence of selected curable sexually transmitted infections \u2013","author":"WHO","year":"2012","unstructured":"WHO. 2012. 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