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Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway and\n            <jats:italic>L. pneumophila<\/jats:italic>\n            has not been well described. Here, we demonstrate that\n            <jats:italic>L. pneumophila<\/jats:italic>\n            inhibits the IFN-\u03b2 signaling pathway but does not inhibit IFN-\u03b3-mediated cell signaling. The addition of IFN-\u03b2 to\n            <jats:italic>L. pneumophila<\/jats:italic>\n            -infected macrophages limited bacterial growth independently of NOS2 and reactive nitrogen species. The type IV secretion system of\n            <jats:italic>L. pneumophila<\/jats:italic>\n            is required to inhibit IFN-\u03b2-mediated cell signaling. Finally, we show that the inhibition of the IFN-\u03b2 signaling pathway occurs downstream of STAT1 and STAT2 phosphorylation. In conclusion, our findings describe a novel host cell signaling pathway inhibited by\n            <jats:italic>L. pneumophila<\/jats:italic>\n            via its type IV secretion system.\n          <\/jats:p>","DOI":"10.1128\/iai.00365-23","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:46:46Z","timestamp":1697464006000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["<i>Legionella pneumophila<\/i>\n            inhibits type I interferon signaling to avoid cell-intrinsic host cell defense"],"prefix":"10.1128","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-7596","authenticated-orcid":false,"given":"Charles N. 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