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Here, we report that inhibition of c-Abl with flumatinib mesylate significantly impairs the survival rate and exacerbates fungal burden in mice infected with\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      . Our findings reveal that c-Abl inhibition reduces production of TNF-\u03b1, IL-10, and IL-12 in bone marrow-derived dendritic cells (BMDCs) after stimulation with fungal \u03b2-glucan or \u03b1-mannan. Mechanistically, c-Abl inhibition significantly blocks p38 and extracellular signal-regulated kinases 1\/2 (ERK1\/2) activation in BMDCs after \u03b1-mannan stimulation in a c-Cbl dependent manner. Collectively, our study uncovers a c-Abl\/c-Cbl\/MAPK signaling axis in dendritic cells that governs antifungal innate immunity, highlighting c-Cbl as a critical downstream mediator linking c-Abl to host defense against\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      . Our findings provide a mechanistic basis for fungal risk assessment in cancer patients treated with c-Abl inhibitors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00365-25","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:00:12Z","timestamp":1769432412000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl\/MAPK pathway"],"prefix":"10.1128","volume":"94","author":[{"given":"Shu-Jun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Naval Military Medical University","place":["Shanghai, China"]},{"name":"Department of Dermatology, The 926th Hospital of PLA","place":["Kaiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5533-6373","authenticated-orcid":false,"given":"Ke-Fang","family":"Xie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]},{"name":"School of Pharmacy, China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Lin","family":"Duan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04hy0x592","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Respiratory and Critical Care Medicine, Institute of Respiratory Medicine, Dongguan Key Laboratory of Immune Inflammation and Metabolism, The First Dongguan Affiliated Hospital, Guangdong Medical University","place":["Dongguan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Long","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4687-1775","authenticated-orcid":true,"given":"Yi-Heng","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rc6as71","id-type":"ROR","asserted-by":"publisher"}],"name":"Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3353-906X","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Naval Military Medical University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408410903241444"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-023-00754-w"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070877"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00687-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11156"},{"key":"e_1_3_3_7_2","first-page":"2213","article-title":"Lymphosarcoma: virus-induced thymic-independent disease in mice","volume":"30","author":"Abelson HT","year":"1970","unstructured":"Abelson HT, Rabstein LS. 1970. 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