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Despite the clinical importance of intra-abdominal candidiasis with mortality rates between 40% and 70%, the contribution of fungal virulence factors and host immune responses to disease has not been extensively studied. Secretion of the quorum-sensing molecule, farnesol, acts as a virulence factor for\n                    <jats:italic>C. albicans<\/jats:italic>\n                    during systemic infection, while inducing local, protective innate immune responses in oral models of infection. Previously, we reported that farnesol recruits macrophages to the peritoneal cavity in mice, suggesting a role for farnesol in innate immune responses. Here, we expand on our initial findings, showing that farnesol profoundly alters the peritoneal cavity microenvironment promoting innate inflammation. Intra-peritoneal injection of farnesol stimulates rapid local death of resident peritoneal cells followed by recruitment of neutrophils and inflammatory macrophages into the peritoneal cavity and peritoneal mesothelium associated with an early increase in chemokines followed by proinflammatory cytokines. These rapid inflammatory responses to farnesol significantly increase morbidity and mortality of mice with intra-abdominal candidiasis associated with increased formation of peritoneal adhesions, despite similar rates of fungal clearance from the peritoneal cavity and retro-peritoneal organs.\n                    <jats:italic>C. albicans ddp3\u0394\/ddp3\u0394<\/jats:italic>\n                    knockout and reconstituted strains recapitulate these findings. This indicates that farnesol may be detrimental to the host during intra-abdominal infections. Importantly, our results highlight a need to understand how\n                    <jats:italic>C. albicans<\/jats:italic>\n                    virulence factors modulate the host immune response within the peritoneum, an exceedingly common site of\n                    <jats:italic>Candida<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1128\/iai.00384-23","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:00:52Z","timestamp":1700211652000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Farnesol remodels the peritoneal cavity immune environment influencing\n                    <i>Candida albicans<\/i>\n                    pathogenesis during intra-abdominal infection"],"prefix":"10.1128","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-9463","authenticated-orcid":true,"given":"Jessica C.","family":"Hargarten","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"},{"name":"Laboratory of Clinical Immunology and Microbiology (LCIM), Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm J.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology (LCIM), Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna T.","family":"Lampe","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"},{"name":"Nebraska Center for Virology, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley M.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"},{"name":"College of Arts and Sciences, Doane University, Crete, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Ssebambulidde","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology (LCIM), Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-6807","authenticated-orcid":true,"given":"Kenneth W.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology (LCIM), Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L.","family":"Atkin","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"},{"name":"Nebraska Center for Virology, University of Nebraska\u2014Lincoln, Lincoln, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Candida and candidosis, a review and biography","author":"Odds FC","year":"1988","unstructured":"Odds FC. 1988. 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