{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:13:21Z","timestamp":1791530001922,"version":"4.3.4"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Longfonds","award":["Accelerate AWWA"],"award-info":[{"award-number":["Accelerate AWWA"]}]},{"name":"UKRI | Medical Research Council","award":["MR\/S000593\/1"],"award-info":[{"award-number":["MR\/S000593\/1"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["221914\/Z\/20\/Z"],"award-info":[{"award-number":["221914\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2024,3,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      HpARI is an immunomodulatory protein secreted by the intestinal nematode\n                      <jats:italic>Heligmosomoides polygyrus bakeri<\/jats:italic>\n                      , which binds and blocks IL-33. Here, we find that the\n                      <jats:italic>H. polygyrus bakeri<\/jats:italic>\n                      genome contains three HpARI family members and that these have different effects on IL-33-dependent responses\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      , with HpARI1+2 suppressing and HpARI3 amplifying these responses. All HpARIs have sub-nanomolar affinity for mouse IL-33; however, HpARI3 does not block IL-33-ST2 interactions. Instead, HpARI3 stabilizes IL-33, increasing the half-life of the cytokine and amplifying responses to it\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Together, these data show that\n                      <jats:italic>H. polygyrus bakeri<\/jats:italic>\n                      secretes a family of HpARI proteins with both overlapping and distinct functions, comprising a complex immunomodulatory arsenal of host-targeted proteins.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00395-23","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:01:38Z","timestamp":1706691698000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses"],"prefix":"10.1128","volume":"92","author":[{"given":"Florent","family":"Colomb","sequence":"first","affiliation":[{"name":"Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adefunke","family":"Ogunkanbi","sequence":"additional","affiliation":[{"name":"Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"},{"name":"Department of Biology, University of York, York, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6842-6056","authenticated-orcid":false,"given":"Abhishek","family":"Jamwal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford, United Kingdom"},{"name":"Kavli Institute for Nanoscience Discovery and Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada"},{"name":"Host-Parasite Interactions Research Training Network, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-8462","authenticated-orcid":true,"given":"Constance A. 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