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Notably, LT\u03b2R-deficient (LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      ) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to\n                      <jats:italic toggle=\"yes\">Toxoplasma gondii<\/jats:italic>\n                      infection. Here, we investigated the bone marrow (BM) and peritoneal cavity (PerC) compartments of LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice during\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection, demonstrating perturbed B-cell and T-cell subpopulations in the absence of LT\u03b2R signaling.\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection disrupted BM lymphopoiesis, depleting early and mature B cells in WT mice, whereas mature B cells remained present in LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      BM. LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      BM also exhibited reduced MHCII\n                      <jats:sup>+<\/jats:sup>\n                      monocytes and a plasma cell compartment skewed toward IgM\n                      <jats:sup>+<\/jats:sup>\n                      rather than IgA\n                      <jats:sup>+<\/jats:sup>\n                      cells. In addition, BM Tcell subsets were altered, exhibiting decreased double-negative (CD4\n                      <jats:sup>-<\/jats:sup>\n                      \/CD8\n                      <jats:sup>-<\/jats:sup>\n                      ) and increased CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell frequencies. Analysis of the BM transcriptome revealed diminished interferon responses but an upregulated TNF\u03b1-NF-\u03baB signaling signature in uninfected and infected LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice, potentially compensating for the absence of LT\u03b2R signaling. LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice displayed an altered B-1a to B-1b ratio and a predominant presence of neutrophils in the PerC. In summary, we identified novel immunological alterations in the BM and PerC compartments of LT\u03b2R\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice, which suggest new roles for LT\u03b2R signaling in B- and T-cell homeostasis, migration, and pathogen defense.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00408-25","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T15:33:07Z","timestamp":1757431987000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Lymphotoxin beta receptor\n                    <sup>-\/-<\/sup>\n                    mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after\n                    <i>Toxoplasma gondii<\/i>\n                    infection"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5656-3230","authenticated-orcid":true,"given":"Marcel","family":"Helle","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024z2rq82","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University","place":["D\u00fcsseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-6117","authenticated-orcid":false,"given":"Ursula R.","family":"Sorg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024z2rq82","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University","place":["D\u00fcsseldorf, 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