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Antibody has been implicated in protection studies in multiple animal models, and we previously showed that the passive transfer of immune serum alone does not confer immunity in the mouse. Using the\n                    <jats:named-content content-type=\"genus-species\">Chlamydia muridarum<\/jats:named-content>\n                    model of genital infection, we demonstrate a protective role for both\n                    <jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>\n                    -specific immunoglobulin G (IgG) and polymorphonuclear neutrophils and show the importance of an antibody\/effector cell interaction in mediating humoral immunity. While neutrophils were found to contribute significantly to antibody-mediated protection\n                    <jats:italic>in vivo<\/jats:italic>\n                    , natural killer (NK) cells were dispensable for protective immunity. Furthermore, gamma interferon (IFN-\u03b3)-stimulated primary peritoneal neutrophils (PPNs) killed chlamydiae\n                    <jats:italic>in vitro<\/jats:italic>\n                    in an antibody-dependent manner. The results from this study support the view that an IFN-\u03b3-activated effector cell population cooperates with antibody to protect against genital chlamydia and establish neutrophils as a key effector cell in this response.\n                  <\/jats:p>","DOI":"10.1128\/iai.00409-17","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T20:20:22Z","timestamp":1500927622000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia"],"prefix":"10.1128","volume":"85","author":[{"given":"Elizabeth K.","family":"Naglak","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra G.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-9884","authenticated-orcid":false,"given":"Richard P.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Global incidence and prevalence of selected curable sexually transmitted infections\u20142008","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. 2012. 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