{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:48:27Z","timestamp":1790095707045,"version":"4.0.1"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The intracellular protozoan parasite\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Toxoplasma gondii<\/jats:named-content>\n                    is a major food-borne illness and opportunistic infection for the immunosuppressed. Resistance to\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Toxoplasma<\/jats:named-content>\n                    is dependent on gamma interferon (IFN-\u03b3) activation of both hematopoietic and nonhematopoietic cells. Although IFN-\u03b3-induced innate immunity in nonhematopoietic cells has been extensively studied in mice, it remains unclear what resistance mechanisms are relied on in nonhematopoietic human cells. Here, we report an IFN-\u03b3-induced mechanism of resistance to\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Toxoplasma<\/jats:named-content>\n                    in primary human foreskin fibroblasts (HFFs) that does not depend on the deprivation of tryptophan or iron. In addition, infection is still controlled in HFFs deficient in the p65 guanylate binding proteins GBP1 or GBP2 and the autophagic protein ATG5. Resistance is coincident with host cell death that is not dependent on the necroptosis mediator RIPK3 or caspases and is correlated with early egress of the parasite before replication. This IFN-\u03b3-induced cell death and early egress limits replication in HFFs and could promote clearance of the parasite by immune cells.\n                  <\/jats:p>","DOI":"10.1128\/iai.00416-13","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T23:04:40Z","timestamp":1379372680000},"page":"4341-4349","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication"],"prefix":"10.1128","volume":"81","author":[{"given":"Wendy","family":"Niedelman","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris K.","family":"Sprokholt","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Cell Biology and Immunology, Wageningen University and Research Centre, Wageningen, The Netherlands"},{"name":"Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Clough","sequence":"additional","affiliation":[{"name":"Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Frickel","sequence":"additional","affiliation":[{"name":"Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen P. 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Human endothelial cells are activated by IFN-\u03b3 to inhibit Toxoplasma gondii replication: inhibition is due to a different mechanism from that existing in mouse macrophages and human fibroblasts. J. Immunol. 147:2019\u20132023.","journal-title":"J. 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