{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:13:12Z","timestamp":1789863192909,"version":"4.0.1"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Meningococcal septic shock is associated with profound vasoplegia, early and severe myocardial dysfunction, and extended skin necrosis responsible for a specific clinical entity designated purpura fulminans (PF). PF represents 90% of fatal meningococcal infections. One characteristic of meningococcal PF is the myocardial dysfunction that occurs in the early phase of sepsis. Furthermore, hemodynamic studies have shown that the prognosis of meningococcal sepsis is directly related to the degree of impairment of cardiac contractility during the initial phase of the disease. To gain insight into a potential interaction of\n            <jats:named-content content-type=\"genus-species\">Neisseria meningitidis<\/jats:named-content>\n            with the myocardial microvasculature, we modified a previously described humanized mouse model by grafting human myocardial tissue to SCID mice. We then infected the grafted mice with\n            <jats:named-content content-type=\"genus-species\">N. meningitides<\/jats:named-content>\n            . Using the humanized SCID mouse model, we demonstrated that\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            targets the human myocardial tissue vasculature, leading to the formation of blood thrombi, infectious vasculitis, and vascular leakage. These results suggest a novel mechanism of myocardial injury in the course of severe\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            sepsis that is likely to participate in primary myocardial dysfunction.\n          <\/jats:p>","DOI":"10.1128\/iai.00420-16","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T03:05:13Z","timestamp":1470107113000},"page":"3017-3023","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Experimental Evidence of Bacterial Colonization of Human Coronary Microvasculature and Myocardial Tissue during Meningococcemia"],"prefix":"10.1128","volume":"84","author":[{"given":"Jean","family":"Bergounioux","sequence":"first","affiliation":[{"name":"INSERM, U1151, Institut Necker Enfants Malades, Paris, France"},{"name":"Universit\u00e9 Versailles Saint Quentin en Yvelines, Versailles, France"},{"name":"Service de Neurologie et R\u00e9animation p\u00e9diatrique, H\u00f4pital Raymond Poincar\u00e9, APHP, Garches, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Coureuil","sequence":"additional","affiliation":[{"name":"INSERM, U1151, Institut Necker Enfants Malades, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Belli","sequence":"additional","affiliation":[{"name":"Centre Chirurgical Marie Lannelongue, Clamard, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ly","sequence":"additional","affiliation":[{"name":"Centre Chirurgical Marie Lannelongue, Clamard, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cambillau","sequence":"additional","affiliation":[{"name":"Service de Biochimie, H\u00f4pital Europ\u00e9en George Pompidou, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goudin","sequence":"additional","affiliation":[{"name":"SFR-Necker Cell Imaging Plateform, Imagine Institut, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[{"name":"INSERM, U1151, Institut Necker Enfants Malades, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Laboratoire de Microbiologie H\u00f4pital Necker-Enfants malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Join-Lambert","sequence":"additional","affiliation":[{"name":"INSERM, U1151, Institut Necker Enfants Malades, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Laboratoire de Microbiologie H\u00f4pital Necker-Enfants malades, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61016-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0535-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318174db05"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000176699.51456.13"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200008000-00049"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15326-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80416-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.7.601"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3563"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit301"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.035"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173196"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198412000-00003"},{"key":"e_1_3_2_15_2","first-page":"986","article-title":"Human\/severe combined immunodeficient mouse chimeras","volume":"91","author":"Yan HC","year":"1993","unstructured":"Yan HC, Juhasz I, Pilewski J, Murphy GF, Herlyn M, Albelda SM. 1993. 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