{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:48:36Z","timestamp":1789876116688,"version":"4.0.1"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Marginal zone B (MZB) cells are a B-cell subset that produces T-cell-independent antibodies to blood-borne antigens. In this study, we examined the effects of MZB cell depletion on the immune response to the Lyme disease spirochete\n                    <jats:italic>Borrelia burgdorferi<\/jats:italic>\n                    , an extracellular pathogen for which T-cell-independent antibody is an important host defense. MZB cell depletion of C3H\/HeJ mice using monoclonal antibody to LFA-1 and \u03b1\n                    <jats:sub>4<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    integrins reduced\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    -specific immunoglobulin M (IgM) titers, enhanced pathogen burden, and led to more severe arthritis assessed within the first 2 weeks of infection. In addition, MZB cell-depleted mice had reduced levels of\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    -specific IgG, which correlated with diminished splenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cell-activation, proliferation, and cytokine production. Passive transfer of immune mouse serum from infected control mice into infected MZB cell-depleted mice reduced pathogen burden but did not alter the expression of T-cell activation markers on splenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These findings demonstrate that MZB cells not only are a source of pathogen-specific IgM important for limiting spirochete burden and pathology but also play a prominent role in the priming of splenic T-cell responses to a blood-borne pathogen.\n                  <\/jats:p>","DOI":"10.1128\/iai.00422-07","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T20:51:24Z","timestamp":1177966284000},"page":"3354-3360","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Marginal Zone B-Cell Depletion Impairs Murine Host Defense against\n                    <i>Borrelia burgdorferi<\/i>\n                    Infection"],"prefix":"10.1128","volume":"75","author":[{"given":"Alexia A.","family":"Belperron","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Dailey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen J.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"Bockenstedt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3740"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.161.4.1710","volume":"161","year":"1998","unstructured":"Amano, M., N. Baumgarth, M. D. Dick, L. Brossay, M. Kronenberg, L. A. Herzenberg, and S. Strober. 1998. CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms. J. Immunol.161:1710-1717.","journal-title":"J. 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