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ATP6AP1 (Ac45) has been implicated in human immune diseases, yet the mechanism underlying how Ac45 regulates immune response and reaction in inflammatory diseases remains unknown. We generated endodontic disease mice through bacterial infection as an inflammatory disease model and used adeno-associated virus (AAV)-mediated\n                    <jats:italic>Ac45<\/jats:italic>\n                    RNA interference knockdown to study the function of Ac45 in periapical inflammation and bone resorption.\n                  <\/jats:p>","DOI":"10.1128\/iai.00436-20","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T11:05:34Z","timestamp":1603105534000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion"],"prefix":"10.1128","volume":"89","author":[{"given":"Wenbin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology, The School of 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