{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:13:36Z","timestamp":1790054016823,"version":"4.0.1"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The role of mouse peptidoglycan recognition protein PGLYRP-1 in innate immunity against\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    infection was studied. The recombinant mouse PGLYRP-1 and a polyclonal antibody specific to PGLYRP-1 were prepared. The mouse PGLYRP-1 showed antibacterial activities against\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    and other Gram-positive bacteria. PGLYRP-1 mRNA expression was induced in the spleens and livers of mice infected with\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    . The viable bacterial number increased, and the production of cytokines such as gamma interferon (IFN-\u03b3) and tumor necrosis factor alpha (TNF-\u03b1) was reduced in mice when mice had been injected with anti-PGLYRP-1 antibody before infection. The levels of IFN-\u03b3 and TNF-\u03b1 titers in the organs were higher and the viable bacterial number was reduced in mice injected with recombinant mouse PGLYRP-1 (rmPGLYRP-1) before infection. PGLYRP-1 could directly induce these cytokines in spleen cell cultures. The elimination of intracellular bacteria was upregulated in NMuLi hepatocyte cells overexpressing PGLYRP-1. The enhancement of the elimination of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    from the organs was observed in IFN-\u03b3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice by rmPGLYRP-1 administration but not in TNF-\u03b1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. These results suggest that PGLYRP-1 plays a role in innate immunity against\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    infection by inducing TNF-\u03b1.\n                  <\/jats:p>","DOI":"10.1128\/iai.00466-10","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T01:20:46Z","timestamp":1291684846000},"page":"858-866","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Mouse Peptidoglycan Recognition Protein PGLYRP-1 Plays a Role in the Host Innate Immune Response against\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1128","volume":"79","author":[{"given":"Arihiro","family":"Osanai","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sashinami","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisana","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Liang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1123"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7404"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00965.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504547102"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701453104"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070216"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3853"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.10.011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00726.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.50"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2128"},{"key":"e_1_3_3_13_2","first-page":"1","volume":"10","year":"2008","unstructured":"Franchi, L., et al. 2008. 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