{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:03:23Z","timestamp":1793660603415,"version":"4.5.1"},"reference-count":209,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Controlled human malaria infection (CHMI) entails deliberate infection with malaria parasites either by mosquito bite or by direct injection of sporozoites or parasitized erythrocytes. When required, the resulting blood-stage infection is curtailed by the administration of antimalarial drugs. Inducing a malaria infection via inoculation with infected blood was first used as a treatment (malariotherapy) for neurosyphilis in Europe and the United States in the early 1900s. More recently, CHMI has been applied to the fields of malaria vaccine and drug development, where it is used to evaluate products in well-controlled early-phase proof-of-concept clinical studies, thus facilitating progression of only the most promising candidates for further evaluation in areas where malaria is endemic. Controlled infections have also been used to immunize against malaria infection. Historically, CHMI studies have been restricted by the need for access to insectaries housing infected mosquitoes or suitable malaria-infected individuals. Evaluation of vaccine and drug candidates has been constrained in these studies by the availability of a limited number of\n                    <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n                    isolates. Recent advances have included cryopreservation of sporozoites, the manufacture of well-characterized and genetically distinct cultured malaria cell banks for blood-stage infection, and the availability of\n                    <jats:named-content content-type=\"genus-species\">Plasmodium vivax<\/jats:named-content>\n                    -specific reagents. These advances will help to accelerate malaria vaccine and drug development by making the reagents for CHMI more widely accessible and also enabling a more rigorous evaluation with multiple parasite strains and species. Here we discuss the different applications of CHMI, recent advances in the use of CHMI, and ongoing challenges for consideration.\n                  <\/jats:p>","DOI":"10.1128\/iai.00479-17","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T20:40:22Z","timestamp":1505767222000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":125,"title":["Controlled Human Malaria Infection: Applications, Advances, and Challenges"],"prefix":"10.1128","volume":"86","author":[{"given":"Danielle I.","family":"Stanisic","sequence":"first","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Queensland, Herston, Queensland, Australia"},{"name":"Clinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Good","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Southport, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1434-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490040092031"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407826-0.00006-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00642-X"},{"key":"e_1_3_2_6_2","first-page":"194","article-title":"Studies in human malaria; trials of quinacrine, colchicine (SN 12,080) and quinine against Chesson strain vivax malaria","volume":"50","author":"Coatney HR","year":"1949","unstructured":"Coatney HR, Cooper WC, Ruhe DS, Young MD. 1949. Studies in human malaria; trials of quinacrine, colchicine (SN 12,080) and quinine against Chesson strain vivax malaria. Am J Hyg (Lond) 50:194\u2013199.","journal-title":"Am J Hyg (Lond)"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09784-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805832"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21060"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw174"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1511-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021914"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.528"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw039"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005254"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004423"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00444-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005070"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241800"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022271"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw244"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv176"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91520-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00414-16"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw225"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005538"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-1079-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis366"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302960"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029025"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005839"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01604"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00481-15"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30139-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2902"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001493"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1975.24.397"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw237"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.05.033"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/427243"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit156"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.223"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90258-G"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90012-N"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065960"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.878"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0504"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.4421-4422.2005"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60360-7"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220360110"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112910"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9099"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.09.057"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.088"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068969"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0613"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00686"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0817-x"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0628-0"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1086\/518510"},{"key":"e_1_3_2_62_2","first-page":"16","article-title":"Controlled human malaria infection at the Walter Reed Army Institute of Research: the past, present, and future from an entomological perspective","volume":"2015","author":"Garver LS","year":"2015","unstructured":"Garver LS, Dowler M, Davidson SA. 2015. Controlled human malaria infection at the Walter Reed Army Institute of Research: the past, present, and future from an entomological perspective. US Army Med Dep J 2015:16\u201324.","journal-title":"US Army Med Dep J"},{"key":"e_1_3_2_63_2","first-page":"52","article-title":"Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes","volume":"63","author":"Verhage DF","year":"2005","unstructured":"Verhage DF, Telgt DS, Bousema JT, Hermsen CC, van Gemert GJ, van der Meer JW, Sauerwein RW. 2005. Clinical outcome of experimental human malaria induced by Plasmodium falciparum-infected mosquitoes. Neth J Med 63:52\u201358.","journal-title":"Neth J Med"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038434"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0119"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.495"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0663-x"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit394"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.09-0498"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099754"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.09-0194"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.11.001"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1301936"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.03.011"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005139"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102287"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505819"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008115"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1086\/339342"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615324114"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89154"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124243"},{"key":"e_1_3_2_83_2","first-page":"1981","article-title":"Tropical malaria contracted the natural way in the Netherlands","volume":"123","author":"Delemarre BJ","year":"1979","unstructured":"Delemarre BJ, van der Kaay HJ. 1979. Tropical malaria contracted the natural way in the Netherlands. Ned Tijdschr Geneeskd 123:1981\u20131982.","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90114-7"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis725"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.03.072"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12276"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097398"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.71.2.0700196"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00379-6"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04942-14"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.9141"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir770"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30139-1"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90206-8"},{"key":"e_1_3_2_96_2","first-page":"625","article-title":"Gametocytocidal and sporontocidal effects of primaquine and of sulfadiazine with pyrimethamine in a chloroquine-resistant strain of Plasmodium falciparum","volume":"38","author":"Rieckmann KH","year":"1968","unstructured":"Rieckmann KH, McNamara JV, Frischer H, Stockert TA, Carson PE, Powell RD. 1968. Gametocytocidal and sporontocidal effects of primaquine and of sulfadiazine with pyrimethamine in a chloroquine-resistant strain of Plasmodium falciparum. Bull World Health Organ 38:625\u2013632.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105787"},{"key":"e_1_3_2_98_2","first-page":"375","article-title":"Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria","volume":"51","author":"Rieckmann KH","year":"1974","unstructured":"Rieckmann KH, Trenholme GM, Williams RL, Carson PE, Frischer H, Desjardins RE. 1974. Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria. Bull World Health Organ 51:375\u2013377.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.3.2.214"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.3.2.207"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1971.20.811"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1972.21.857"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1975.24.734"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.226"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1972.21.138"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/134.9.802"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1967.11686504"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1976.25.769"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.767"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1982.31.1075"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30171-8"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41975"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12962"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw128"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(47)90025-4"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197309000-00002"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00590-06"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.12.041"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu579"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1086\/339409"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm881"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3836"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.03.083"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.2706-2716.2006"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406381102"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1086\/515331"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055571"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.07.067"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1435-y"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4110"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.22129"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.24941"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131571"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.603"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.1066"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90540-X"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.45.539"},{"key":"e_1_3_2_138_2","first-page":"33","article-title":"Human studies with synthetic peptide sporozoite vaccine (NANP)3-TT and immunization with irradiated sporozoites","volume":"68","author":"Herrington DA","year":"1990","unstructured":"Herrington DA, Clyde DF, Davis JR, Baqar S, Murphy JR, Cortese JF, Bank RS, Nardin E, DiJohn D, Nussenzweig RS, Nussenzweig V, Torres JR, Murillo J, Cortesia M, Sturchler D, Hollingdale M, Levine MM. 1990. Human studies with synthetic peptide sporozoite vaccine (NANP)3-TT and immunization with irradiated sporozoites. Bull World Health Organ 68(Suppl):33\u201337.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.06.033"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1086\/515657"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.046"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1086\/600120"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.02.048"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1086\/318534"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.05.005"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106241"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025868"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.5.2863-2872.2005"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(74)90129-1"},{"key":"e_1_3_2_150_2","first-page":"S261","article-title":"Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria","volume":"57","author":"Rieckmann KH","year":"1979","unstructured":"Rieckmann KH, Beaudoin RL, Cassells JS, Sell KW. 1979. Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria. Bull World Health Organ 57(Suppl 1):S261\u2013S265.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360202"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197312000-00001"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0621"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix053"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2009.07.004"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-4-21"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162349899"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1086\/519844"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07664.x"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08399.x"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.01008.x"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02096-2"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107903"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12226"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00473-15"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201455"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu354"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.162"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040587"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-24.x"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002389"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.08.006"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5736"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115889"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02160.x"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00408-06"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.03069-14"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939434"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039000"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12428"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.02.023"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu293"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.07.087"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5675"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31291"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-136"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep03549"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00986-16"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.017"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01522-15"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601989"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136109"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1019186"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003978"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621489114"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12608"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.49.166"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.10.997"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90303-V"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00557"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1348-9"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2003.00495.x"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6961"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.007948"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061395"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.098"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020775"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1086\/650310"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163026"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-185"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00479-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00479-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:48:52Z","timestamp":1646459332000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00479-17"}},"subtitle":[],"editor":[{"given":"Helene L.","family":"Andrews-Polymenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":209,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1128\/IAI.00479-17"],"URL":"https:\/\/doi.org\/10.1128\/iai.00479-17","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731246289.793573198","asserted-by":"object"}]},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00479-17"}}