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Hospital outbreaks driven by multi-drug-resistant pathogens, notably\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      ), are of grave concern. This opportunistic pathogen causes pneumonia, urinary tract infections, and bacteremia, particularly in immunocompromised individuals. The rise of hypervirulent\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      adds complexity, as it increasingly infects healthy individuals. Recent epidemiological data suggest that asymptomatic gastrointestinal carriage serves as a reservoir for infections in the same individual and allows for host-to-host transmission\n                      <jats:italic>via<\/jats:italic>\n                      the fecal-oral route. This review focuses on\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      \u2019s gastrointestinal colonization, delving into epidemiological evidence, current animal models, molecular colonization mechanisms, and the protective role of the resident gut microbiota. Moreover, the review sheds light on\n                      <jats:italic>in vivo<\/jats:italic>\n                      high-throughput approaches that have been crucial for identifying\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      factors in gut colonization. This comprehensive exploration aims to enhance our understanding of\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      gut pathogenesis, guiding future intervention and prevention strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00482-23","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T09:00:53Z","timestamp":1712739653000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Deciphering the gastrointestinal carriage of\n                    <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"92","author":[{"given":"Andrew S.","family":"Bray","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-0422","authenticated-orcid":true,"given":"M. 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