{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:56:49Z","timestamp":1791489409391,"version":"4.3.4"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Treponema denticola<\/jats:italic>\n                    is considered an important oral pathogen in the development and progression of periodontal diseases. In the present study, the mechanisms of recognition and activation of murine macrophages by\n                    <jats:italic>T. denticola<\/jats:italic>\n                    and its major outer sheath protein (MSP) and lipooligosaccharide (LOS or glycolipid) were investigated.\n                    <jats:italic>T. denticola<\/jats:italic>\n                    cells and the MSP induced innate immune responses through TLR2-MyD88, whereas LOS induced a macrophage response through TLR4-MyD88. The presence of gamma interferon (IFN-\u03b3), or of high numbers of\n                    <jats:italic>T. denticola<\/jats:italic>\n                    , circumvented the requirement for TLR2 for the macrophage response to\n                    <jats:italic>T. denticola<\/jats:italic>\n                    , although the response was still dependent on MyD88. In contrast, synergy with IFN-\u03b3 did not alter the TLR dependence of the response to the\n                    <jats:italic>T. denticola<\/jats:italic>\n                    surface components LOS and MSP, despite enhanced sensitivity. These data suggest that although there is flexibility in the requirements for recognition of\n                    <jats:italic>T. denticola<\/jats:italic>\n                    cells (TLR2 dependent or independent), MyD88 is a requirement for the downstream signaling events that lead to inflammation. We also demonstrate that both outer sheath molecules LOS and MSP induce macrophage tolerance to further stimulation with enterobacterial lipopolysaccharide. Tolerance induced by\n                    <jats:italic>T. denticola<\/jats:italic>\n                    components during mixed infections may represent a general mechanism through which bacteria evade clearance.\n                  <\/jats:p>","DOI":"10.1128\/iai.00488-09","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T20:54:13Z","timestamp":1247518453000},"page":"3939-3947","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to\n                    <i>Treponema denticola<\/i>\n                    and Its Outer Sheath Components"],"prefix":"10.1128","volume":"77","author":[{"given":"Gabriel","family":"Nussbaum","sequence":"first","affiliation":[{"name":"Institute of Dental Sciences, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Ben-Adi","sequence":"additional","affiliation":[{"name":"Institute of Dental Sciences, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Genzler","sequence":"additional","affiliation":[{"name":"Institute of Dental Sciences, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sela","sequence":"additional","affiliation":[{"name":"Institute of Dental Sciences, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Rosen","sequence":"additional","affiliation":[{"name":"Institute of Dental Sciences, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2382-2388.1997"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.717-725.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00448.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.04.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986706778201675"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4072-4083.1999"},{"key":"e_1_3_2_8_2","first-page":"67","volume":"31","year":"2008","unstructured":"Cavrini, F., C. 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