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It is commonly acquired by mammals such as rodents and humans via the bite of an infected flea. We previously reported that multiple substrains of the 129 mouse background are resistant to pigmentation locus-negative (pgm<jats:sup>\u2212<\/jats:sup>)<jats:named-content content-type=\"genus-species\">Yersinia pestis<\/jats:named-content>and that this phenotype maps to a 30-centimorgan (cM) region located on chromosome 1. In this study, we have further delineated this plague resistance locus to a region of less than 20 cM through the creation and phenotyping of recombinant offspring arising from novel crossovers in this region. Furthermore, our experiments have revealed that there are at least two alleles in this initial locus, both of which are required for resistance on a susceptible C57BL\/6 background. These two alleles work in<jats:italic>trans<\/jats:italic>since resistance is restored in offspring possessing one allele contributed by each parent. Our studies also indicated that the Slc11a1 gene (formerly known as Nramp1) located within the chromosome1 locus is not responsible for conferring resistance to 129 mice.<\/jats:p>","DOI":"10.1128\/iai.00488-16","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T03:05:13Z","timestamp":1470107113000},"page":"2904-2913","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1"],"prefix":"10.1128","volume":"84","author":[{"given":"Michael","family":"Tencati","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard I.","family":"Tapping","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, University of Illinois at Urbana\u2014Champaign, Urbana, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/428617"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2101.131828"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2012.34"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.9866"},{"key":"e_1_3_2_6_2","first-page":"131","article-title":"Studies on immunization against plague. 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