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To experimentally test the role of IL-6, responses to an intracellular<jats:italic>Leishmania donovani<\/jats:italic>infection in the livers of IL-6<jats:sup>\u2212\/\u2212<\/jats:sup>and wild-type mice were compared. IL-6<jats:sup>\u2212\/\u2212<\/jats:sup>mice showed an enhanced control of the infection and earlier, rapid parasite killing along with additional evidence of a stimulated antileishmanial Th1-cell-type response: increased levels of circulating gamma interferon, accelerated granuloma assembly, and heightened responsiveness to chemotherapy. In this model of visceral leishmaniasis, IL-6 appears to act in a suppressive, macrophage-deactivating fashion, which identifies it as a potential target for therapeutic blockade.<\/jats:p>","DOI":"10.1128\/iai.00490-08","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T00:55:18Z","timestamp":1214268918000},"page":"4088-4091","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Accelerated Control of Visceral<i>Leishmania donovani<\/i>Infection in Interleukin-6-Deficient Mice"],"prefix":"10.1128","volume":"76","author":[{"given":"Henry W.","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Medicine, Weill Cornell Medical College, New York, New York 10065"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00578.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.01.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/506624"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1541"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.153.10.4583","volume":"153","year":"1994","unstructured":"Beaman, M. 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