{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:30:17Z","timestamp":1787016617608,"version":"build-2736575974"},"reference-count":218,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM154838"],"award-info":[{"award-number":["1R35GM154838"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2025,8,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Neutrophils are the most abundant leukocytes at sites of inflammation and form the front line of the innate immune response. Neutrophils have a relatively short lifespan compared to other cell types, as they have streamlined their metabolic processes to support an arsenal of antimicrobial functions to combat invading pathogens at the cost of maximizing ATP output. To elicit antimicrobial stress, neutrophils rewire their glycolytic pathways to sustain phagocytosis and the oxidative burst and modify their mitochondrial metabolism to dictate degranulation or release of neutrophil extracellular traps. While many of these effector functions are sufficient to protect the \u201chealthy\u201d host from infection, chronic diseases disrupting metabolic and inflammatory homeostasis render the host susceptible to more frequent and severe bacterial infections. With the growing incidence of many metabolic and autoimmune diseases, a clearer understanding of the mechanisms regulating or disrupting neutrophil antimicrobial processes is required. This review focuses on the relationship between neutrophil function and metabolism and what is known about how this impacts autoimmune and metabolic diseases and\/or disorders in the case of bacterial infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00498-24","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T10:52:03Z","timestamp":1751280723000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Live fast, die young: neutrophils streamline their metabolism to maximize inflammation"],"prefix":"10.1128","volume":"93","author":[{"given":"Bailey E.","family":"Holder","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Tennessee","place":["Knoxville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callista P.","family":"Reber","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee","place":["Knoxville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7259-6574","authenticated-orcid":true,"given":"Andrew J.","family":"Monteith","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Tennessee","place":["Knoxville, USA"]},{"id":[{"id":"https:\/\/ror.org\/020f3ap87","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee","place":["Knoxville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9233"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2012.2012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.76.1.158"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.12.6732"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108553"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605898200"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106134200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.07.005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.013"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01333-19"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004975"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.2.328-336.1992"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050846"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406143101"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01524-06"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6337-6345.2000"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00146-21"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13997"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.28.2.277"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2985.2985"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.6.5.761-765.1972"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.2.423.423"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/416291a"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4945"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112120"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.3.799.799"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114312"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3270917"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3629236"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.2.804"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.125302"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.124.2.855"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.4.1535"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.9.1067"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1829"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700261"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00304-23"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003093"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006052"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.496"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24437"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001321"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414055112"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4027"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00685-21"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00551-21"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj2101"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100752"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137866"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165664"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2017.03.003"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-290171"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.044"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909546117"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6676"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111688"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41749"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000675"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2847"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.11.008"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-171629"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319909"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114969"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax7942"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406641102"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99445"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09683-z"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002329"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2407-8"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01166-3"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721949115"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-700336"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1964"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12437"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci110647"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302059"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401320"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01786.x"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00350.2006"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00916406"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.640094"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70011-2"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.3.933"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-258491"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.016"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijabmr.IJABMR_350_18"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1159\/000459647"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040910110"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624775"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1989.50.07.1175"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00550-8"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.041"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607194018002128"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030403"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309520200"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002724"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00491-3"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.53"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002013"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.572495"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.02.003"},{"key":"e_1_3_2_105_2","first-page":"360","article-title":"The influence of bacterial species on pulmonary resistance to infection in mice subjected to hypoxia, cold stress, and ethanolic intoxication","volume":"46","author":"Green GM","year":"1965","unstructured":"Green GM, Kass EH. 1965. The influence of bacterial species on pulmonary resistance to infection in mice subjected to hypoxia, cold stress, and ethanolic intoxication. Br J Exp Pathol 46:360\u2013366.","journal-title":"Br J Exp Pathol"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00175-15"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005341"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03947.x"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.08.005"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf024"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07505-2"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00260"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12107"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.09.005"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12631"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902199"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780291105"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4681"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100123"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202218"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb01334.x"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-1759(99)00176-3"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0310162"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318274647d"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235272"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085696"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153567"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1107"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0375-7"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08089-5"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672520"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02761"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.252528"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi7438"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666191024085838"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30058-2"},{"key":"e_1_3_2_137_2","volume-title":"Insulin resistance","author":"Freeman AM","year":"2024","unstructured":"Freeman AM, Acevedo LA, Pennings N. 2024. Insulin resistance. StatPearls, Treasure Island (FL)."},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-2975-2"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1672-5"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2224"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1086\/431587"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5569"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00163-19"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add3221"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00745.x"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400406"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4991"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.663"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1451"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.812"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2021.106098"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3064"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-12-199512150-00004"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-121723"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.2.256"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.6.869"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-2-402"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3887"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0676-x"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.34133\/research.0365"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109193251202"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.07.016"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14245255"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08741-5"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42330"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206334"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223035"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2904"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.09.003"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00213.x"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.d01-717.x"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00664-06"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.711423"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.565981"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.153993"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.11.916"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.09.005"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.11.009"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138065"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6484.1797"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000233834.09743.3b"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101982"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7410"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0040-5"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2014.05.003"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0007-y"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-56"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094359"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500418"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513943113"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2776(01)76021-x"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-004-1040-2"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213181"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909927107"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380509"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078459"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key067"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41128"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf1933"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203794"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314537697"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159384"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-015-0772-0"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037210"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4169-0"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-023-06539-2"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211006790"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2019-000332"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.20900\/immunometab20210025"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu170oa"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198709000-00002"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken196"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1079-x"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2764"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00498-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/iai.00498-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T13:01:05Z","timestamp":1755003665000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/iai.00498-24"}},"subtitle":[],"editor":[{"given":"Anthony R.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":218,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,12]]}},"alternative-id":["10.1128\/iai.00498-24"],"URL":"https:\/\/doi.org\/10.1128\/iai.00498-24","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"2025-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00498-24"}}