{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:19:52Z","timestamp":1782386392032,"version":"3.54.5"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The rodent hookworm<jats:italic>Nippostrongylus brasiliensis<\/jats:italic>typically infects its host by penetrating the skin and rapidly migrating to the lungs and gut. Following primary infection, immunocompetent mice become highly protected from reinfection with<jats:italic>N. brasiliensis<\/jats:italic>, with the numbers of worms gaining access to the lungs and gut being reduced by up to 90%. We used green fluorescent protein\/interleukin-4 (IL-4) reporter mice and truncated infection studies to identify both the tissue site and mechanism(s) by which the host protects itself from reinfection with<jats:italic>N. brasiliensis<\/jats:italic>. Strikingly, we demonstrated that the lung is an important site for priming immune protection. Furthermore, a lung-initiated, CD4 T-cell-dependent, and IL-4- and STAT6-dependent response was sufficient to confer protection against reinfection. In conclusion, vaccination strategies which seek to break the cycle of reinfection and egg production by helminths such as hookworms can include strategies which directly stimulate Th2 responses in the lung.<\/jats:p>","DOI":"10.1128\/iai.00502-09","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T02:22:06Z","timestamp":1278469326000},"page":"3753-3762","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["The Lung Is an Important Site for Priming CD4 T-Cell-Mediated Protective Immunity against Gastrointestinal Helminth Parasites"],"prefix":"10.1128","volume":"78","author":[{"given":"Marina","family":"Harvie","sequence":"first","affiliation":[{"name":"Malaghan Institute of Medical Research, P.O. Box 7060, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Camberis","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research, P.O. Box 7060, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiau-Choot","family":"Tang","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research, P.O. Box 7060, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Delahunt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Paul","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland 20892-1892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Le Gros","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research, P.O. Box 7060, Wellington, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.4984"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.140.10.3573","volume":"140","year":"1988","unstructured":"Aitken, R., P. S. Coulson, and R. A. Wilson. 1988. Pulmonary leukocytic responses are linked to the acquired immunity of mice vaccinated with irradiated cercariae of Schistosoma mansoni. J. Immunol.140:3573-3579.","journal-title":"J. Immunol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.840"},{"key":"e_1_3_2_5_2","unstructured":"Curr. Protoc. Immunol. 2003 19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.1.42-48.1997"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5315-5323.1999"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00332-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.505"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00192.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.07.091"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00248-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00084-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7454"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.4049\/jimmunol.140.9.3206","volume":"140","year":"1988","unstructured":"Katona, I. M., J. F. Urban, Jr., and F. D. Finkelman. 1988. The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunol.140:3206-3211.","journal-title":"J. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.754"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182008005192"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.04.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/362245a0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737827"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00974.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.143.7.2342","volume":"143","year":"1989","unstructured":"Menson, E. N., and R. A. Wilson. 1989. Lung-phase immunity to Schistosoma mansoni. Flow cytometric analysis of macrophage activation states in vaccinated mice. J. Immunol.143:2342-2348.","journal-title":"J. Immunol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.385-394.2005"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2607-2614.2003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00687-06"},{"key":"e_1_3_2_26_2","first-page":"45","volume":"114","year":"1997","unstructured":"Shin, E. H., Y. Osada, J. Y. Chai, N. Matsumoto, K. Takatsu, and S. Kojima. 1997. Protective roles of eosinophils in Nippostrongylus brasiliensis infection. Int. Arch. Allergy Immunol.114(Suppl. 1):45-50.","journal-title":"Int. Arch. Allergy Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5837"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.5314-5323.2003"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80477-X"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806372105"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00502-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00502-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T23:44:07Z","timestamp":1685663047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00502-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1128\/IAI.00502-09"],"URL":"https:\/\/doi.org\/10.1128\/iai.00502-09","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"2009-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}