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We utilized a flow-cytometry-based assay to determine whether serum samples from a well-characterized cohort of CT-infected and na\u00efve control individuals enhanced phagocytosis via Fc-receptor-expressing THP-1 cells, and whether this activity correlated with antibody titers. Fc-receptor-mediated phagocytosis was detected only in CT+ donors. Phagocytosis generally did not correlate well with antibody titer. In addition, we found that complement from both CT+ and negative individuals enhanced phagocytosis of CT into primary neutrophils. These results suggest that anti-CT antibodies can have functions that are not reflected by titer. This method could be used to quantitively measure Fc-receptor-mediated function of anti-CT antibodies or complement activity and could reveal new immune correlates of protection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00503-23","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T09:01:01Z","timestamp":1709802061000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Antibodies from chlamydia-infected individuals facilitate phagocytosis via Fc receptors"],"prefix":"10.1128","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-3079","authenticated-orcid":true,"given":"Kevin","family":"Hybiske","sequence":"first","affiliation":[{"name":"Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, 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