{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:10:53Z","timestamp":1759936253387,"version":"3.41.2"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2017YFD0500203","2018YFD0500100"],"award-info":[{"award-number":["2017YFD0500203","2018YFD0500100"]}]},{"DOI":"10.13039\/501100013058","name":"Primary Research and Development Plan of Jiangsu Province","doi-asserted-by":"crossref","award":["BE2017341"],"award-info":[{"award-number":["BE2017341"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD"],"award-info":[{"award-number":["PAPD"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872480","31672574","31860706"],"award-info":[{"award-number":["31872480","31672574","31860706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,10,19]]},"abstract":"<jats:p>\n            Porcine circovirus type 2 (PCV2) and\n            <jats:named-content content-type=\"genus-species\">Streptococcus suis<\/jats:named-content>\n            serotype 2 (SS2) clinical coinfection cases have been frequently detected. The respiratory epithelium plays a crucial role in host defense against a variety of inhaled pathogens. Reactive oxygen species (ROS) are involved in killing of bacteria and host immune response. The aim of this study is to assess whether PCV2 and SS2 coinfection in swine tracheal epithelial cells (STEC) affects ROS production and investigate the roles of ROS in bacterial survival and the inflammatory response.\n          <\/jats:p>","DOI":"10.1128\/iai.00537-20","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T13:45:45Z","timestamp":1598881545000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Coinfection with Porcine Circovirus Type 2 (PCV2) and Streptococcus suis Serotype 2 (SS2) Enhances the Survival of SS2 in Swine Tracheal Epithelial Cells by Decreasing Reactive Oxygen Species Production"],"prefix":"10.1128","volume":"88","author":[{"given":"Qing","family":"Wang","sequence":"first","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-0133","authenticated-orcid":false,"given":"Hongjie","family":"Fan","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-031412-103720"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0389.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.02.006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063870201400614"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2017.10.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1660233"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.06.025"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2008.01035.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12364"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-10"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuy045"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00141514"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005923"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-123"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4123854"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.095216"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.10.011"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13659"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03529-14"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-020-00756-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2741\/4848"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00884.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704467"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000496370"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001840"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.237"},{"key":"e_1_3_2_30_2","first-page":"211","article-title":"The expression of NADPH oxidases and production of reactive oxygen species by human lung adenocarcinoma epithelial cell line A549","volume":"56","author":"Kol\u00e1\u0159ov\u00e1 H","year":"2010","unstructured":"Kol\u00e1\u0159ov\u00e1 H, Bin\u00f3 L, Pejchalov\u00e1 K, Kubala L. 2010. The expression of NADPH oxidases and production of reactive oxygen species by human lung adenocarcinoma epithelial cell line A549. Folia Biol (Praha) 56:211\u2013217.","journal-title":"Folia Biol (Praha)"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006438"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4350965"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2360-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2019.04.028"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.05.77"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005382"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00537-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00537-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:34:31Z","timestamp":1646480071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00537-20"}},"subtitle":[],"editor":[{"given":"Guy H.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,10,19]]}},"alternative-id":["10.1128\/IAI.00537-20"],"URL":"https:\/\/doi.org\/10.1128\/iai.00537-20","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"type":"print","value":"0019-9567"},{"type":"electronic","value":"1098-5522"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"2020-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00537-20"}}