{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:24:01Z","timestamp":1790663041671,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Pneumococcal surface protein C (PspC) is a virulence factor of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            previously shown to play a role in bacterial adherence, invasion, and evasion of complement. We investigated the role of this protein in our murine models of pneumococcal pneumonia with different pneumococcal strains. The deletion of\n            <jats:italic>pspC<\/jats:italic>\n            in strains of serotypes 2, 3, and 19F did not significantly alter host survival times in the pneumonia model. In contrast,\n            <jats:italic>pspC<\/jats:italic>\n            deletion significantly reduced the virulence of the serotype 4 strain, TIGR4, in both the pneumonia and bacteremia models. Therefore,\n            <jats:italic>pspC<\/jats:italic>\n            is a systemic and pulmonary virulence determinant for\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            , but its effects are influenced by the pneumococcal strain. Finally, pneumonia infection of complement-deficient (C3\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ) mice enhanced\n            <jats:italic>pspC<\/jats:italic>\n            virulence, illustrating that PspC-mediated complement evasion contributes to virulence. However, other functions of PspC also contribute to virulence, as demonstrated by the finding that the\n            <jats:italic>pspC<\/jats:italic>\n            -deficient TIGR4 mutant was still attenuated relative to the wild-type parent, even in the absence of C3.\n          <\/jats:p>","DOI":"10.1128\/iai.00543-06","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T22:13:07Z","timestamp":1156284787000},"page":"5319-5324","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["The Contribution of PspC to Pneumococcal Virulence Varies between Strains and Is Accomplished by Both Complement Evasion and Complement-Independent Mechanisms"],"prefix":"10.1128","volume":"74","author":[{"given":"Alison R.","family":"Kerr","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow, G12 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin K.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow, G12 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow, G12 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Iannelli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Biotechnology, Department of Molecular Biology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R.","family":"Oggioni","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Biotechnology, Department of Molecular Biology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Biotechnology, Department of Molecular Biology, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow, G12 8TA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.12.5683-5688.1994"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2526-2534.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4405-4413.2003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.4925-4935.2003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.12.6533-6542.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012669199"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2615-2625.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3435-3437.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.471"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310528200"},{"key":"e_1_3_2_12_2","first-page":"1389","volume":"45","year":"2002","unstructured":"Hava, D., and A. 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