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An effective immune response must carefully balance controlling\n                      <jats:italic toggle=\"yes\">C. difficile<\/jats:italic>\n                      -mediated pathology and systemic dissemination of opportunistic bacteria while avoiding collateral immunopathology. In addition, a successful immune response must also promote restorative mechanisms to repair toxin-induced disruptions to the intestinal barrier. Here, we review the immune response to\n                      <jats:italic toggle=\"yes\">C. difficile<\/jats:italic>\n                      infection with a specific focus on the role of innate immune-induced cytokines.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00551-25","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:29:26Z","timestamp":1784298566000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Balancing act of cytokines in controlling the severity of\n                    <i>Clostridioides difficile<\/i>\n                    infection"],"prefix":"10.1128","volume":"94","author":[{"given":"Kevin S.","family":"Mears","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Perelman School of Medicine, University of 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