{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:20:11Z","timestamp":1778592011692,"version":"3.51.4"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["50-53000-98-139"],"award-info":[{"award-number":["50-53000-98-139"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:p>\n            Respiratory epithelial cells are important for pulmonary innate immune responses during\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            infection. Tet methylcytosine dioxygenase 2 (Tet2) has been implicated in the regulation of host defense by myeloid and lymphoid cells, but whether Tet2 also contributes to epithelial responses during pneumonia is unknown. The aim of this study was to investigate the role of bronchial epithelial Tet2 in acute pneumonia caused by\n            <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n            . To this end, we crossed mice with\n            <jats:italic>Tet2<\/jats:italic>\n            flanked by two Lox-P sites (\n            <jats:italic>\n              Tet2\n              <jats:sup>fl\/fl<\/jats:sup>\n            <\/jats:italic>\n            mice) with mice expressing Cre recombinase under the bronchial epithelial cell-specific\n            <jats:italic>Cc10<\/jats:italic>\n            promoter (\n            <jats:italic>\n              Cc10\n              <jats:sup>Cre<\/jats:sup>\n            <\/jats:italic>\n            mice) to generate bronchial epithelial cell-specific Tet2-deficient (\n            <jats:italic>\n              Tet2\n              <jats:sup>fl\/fl<\/jats:sup>\n              Cc10\n              <jats:sup>Cre<\/jats:sup>\n            <\/jats:italic>\n            ) mice.\n          <\/jats:p>","DOI":"10.1128\/iai.00603-20","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T13:54:19Z","timestamp":1602165259000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Bronchial Epithelial Tet2 Maintains Epithelial Integrity during Acute Pseudomonas aeruginosa Pneumonia"],"prefix":"10.1128","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-5007","authenticated-orcid":false,"given":"Wanhai","family":"Qin","sequence":"first","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xanthe","family":"Brands","sequence":"additional","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"van't Veer","sequence":"additional","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex F.","family":"de Vos","sequence":"additional","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon P.","family":"Scicluna","sequence":"additional","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Department of Clinical Epidemiology and Biostatistics, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"van der Poll","sequence":"additional","affiliation":[{"name":"Center of Experimental &amp; Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Division of Infectious Diseases, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201705-1043SO"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12033"},{"key":"e_1_3_3_4_2","volume-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"Tacconelli E","year":"2017","unstructured":"Tacconelli E, Magrini N. 2017. 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