{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:09Z","timestamp":1792787229603,"version":"4.5.0"},"reference-count":75,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH","award":["TR001859"],"award-info":[{"award-number":["TR001859"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2025,9,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      While\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      is a common, commensal yeast colonizing 50%\u201360% of humans, it has the potential to expand in the gastrointestinal tract and enter the blood stream resulting in invasive candidiasis. Invasive candidiasis carries a mortality approaching 50%, especially in the most vulnerable, immunocompromised population. Antibacterial use causes an increase in\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      gastrointestinal colonization, indicating that the colonic microbiota plays a major role in preventing an uncontrolled expansion, a phenomenon known as colonization resistance. Antibacterials, medications, diet, and co-morbid conditions can all alter the microbiome, creating an altered environment known as dysbiosis. Our understanding of the microbiome continues to advance, and there is increasing evidence that the interactions that the microbiome has on the host are vital in maintaining colonization resistance to pathogens including\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      . This review will focus on colonization resistance to\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      within the gastrointestinal tract. The scope includes the benefits and consequences of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      colonization, interkingdom interactions of the microbiome on\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      , microbiome-host interactions and how these modulate\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      colonization, and the impact of medications and diet on colonization resistance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/iai.00610-24","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:47:13Z","timestamp":1754920033000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["<i>Candida albicans<\/i>\n                    gastrointestinal colonization resistance: a host-microbiome balancing act"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-5569","authenticated-orcid":true,"given":"Derek J.","family":"Bays","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, University of California Davis","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah P.","family":"Savage","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rrcem69","id-type":"ROR","asserted-by":"publisher"}],"name":"Department Medical Microbiology and Immunology, School of Veterinary Medicine, University of California Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00203-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1608-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv209"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009710"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04502-w"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0709-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S459600"},{"key":"e_1_3_2_10_2","unstructured":"Anonymous. 2022. 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