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Here we show that hTERT is critical for<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Listeria monocytogenes<\/jats:named-content>infection, as the depletion of hTERT impaired bacterial intracellular replication. In addition, we observed that<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">L. monocytogenes<\/jats:named-content>caused a decrease in hTERT levels at early time points of the infectious process. This effect was mediated by the pore-forming toxin listeriolysin O (LLO) and did not require bacterial entry into host cells. Calcium influx through the LLO pores contributed to a proteasome-independent decrease in hTERT protein levels. Together, our data provide evidence that these bacteria trigger hTERT degradation, an event that is detrimental to bacterial replication.<\/jats:p>","DOI":"10.1128\/iai.00614-12","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T10:25:58Z","timestamp":1348568758000},"page":"4257-4263","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Role for Telomerase in Listeria monocytogenes Infection"],"prefix":"10.1128","volume":"80","author":[{"given":"Ascel","family":"Samba-Louaka","sequence":"first","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France; INSERM, U604, Paris, France; and INRA, USC 2020, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"Stavru","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France; INSERM, U604, Paris, France; and INRA, USC 2020, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France; INSERM, U604, Paris, France; and INRA, USC 2020, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.019372"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142412"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm269"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.04.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.349"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00750.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000637200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112371108"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401670"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.12.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3614-3618.2003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-28"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.11.2822-2829.1987"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144683"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201081"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.7.2729-2737.1995"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90170-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01243-10"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.04.006"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0921-8734(91)90018-7"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.05.015"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/365182a0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603671"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.4049\/jimmunol.155.8.3711","article-title":"Activation of telomerase in human lymphocytes and hematopoietic progenitor cells","volume":"155","author":"Hiyama K","year":"1995","unstructured":"HiyamaK. 1995. 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