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The fallopian tubes and vagina are poorly suited to surveillance and defense, with limited immune infrastructure positioned near the epithelium. However, a dynamic process during clearing primary infections leaves behind new lymphoid clusters immediately beneath the epithelium. These memory lymphocyte clusters (MLCs) harboring tissue-resident memory (Trm) T cells are presumed to play an important role in protection from subsequent infections. Histologically, human<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>MLCs have prominent B cell populations. We investigated the status of genital tract B cells during<jats:named-content content-type=\"genus-species\">C. muridarum<\/jats:named-content>infections and the nature of T cells recovered from immune mice using immune B cells as antigen-presenting cells (APCs). These studies revealed a genital tract plasma B cell population and a novel genital tract CD4 T cell subset producing both gamma interferon (IFN-\u03b3) and interleukin-13 (IL-13). A panel of CD4 T cell clones and microarray analysis showed that the molecular fingerprint of CD4\u03b313 T cells includes a Trm-like transcriptome. Adoptive transfer of a<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>-specific CD4\u03b313 T cell clone completely prevented oviduct immunopathology without accelerating bacterial clearance. Existence of a CD4\u03b313 T cell subset provides a plausible explanation for the observation that human peripheral blood mononuclear cell (PBMC)<jats:named-content content-type=\"genus-species\">Chlamydia<\/jats:named-content>-specific IFN-\u03b3 and IL-13 responses predict resistance to reinfection.<\/jats:p>","DOI":"10.1128\/iai.00614-17","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T16:30:21Z","timestamp":1511195421000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4\u03b313 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters"],"prefix":"10.1128","volume":"86","author":[{"given":"Raymond M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, 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