{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:10:30Z","timestamp":1774793430087,"version":"3.50.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The gram-negative bacterium\n            <jats:italic>Bartonella henselae<\/jats:italic>\n            is capable of causing angiogenic lesions as a result of infection. Previously, it has been shown that\n            <jats:italic>B. henselae<\/jats:italic>\n            infection can result in production of the chemokine interleukin-8 (IL-8). In this study, we demonstrated that monocytes, endothelial cells, and hepatocytes produce IL-8 in response to\n            <jats:italic>B. henselae<\/jats:italic>\n            infection. We also investigated the role of IL-8 in\n            <jats:italic>B. henselae<\/jats:italic>\n            -induced endothelial cell proliferation and capillary tube formation. Both in vitro angiogenesis assays were IL-8 dependent.\n            <jats:italic>B. henselae<\/jats:italic>\n            -mediated inhibition of apoptosis, as indicated by gene expression of\n            <jats:italic>Bax<\/jats:italic>\n            and\n            <jats:italic>Bcl-2<\/jats:italic>\n            , was also shown to be IL-8 dependent in endothelial cells. Furthermore, infection of endothelial cells with\n            <jats:italic>B. henselae<\/jats:italic>\n            stimulated upregulation of the IL-8 chemokine receptor CXCR2. Infection of human endothelial cells by\n            <jats:italic>B. henselae<\/jats:italic>\n            resulting in IL-8 production likely plays a central role in the ability of this organism to cause angiogenesis during infection.\n          <\/jats:p>","DOI":"10.1128\/iai.00622-06","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T22:13:07Z","timestamp":1156284787000},"page":"5185-5190","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Autocrine Role for Interleukin-8 in\n            <i>Bartonella henselae<\/i>\n            -Induced Angiogenesis"],"prefix":"10.1128","volume":"74","author":[{"given":"Amy M.","family":"McCord","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, Tampa, Florida 33612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra I.","family":"Resto-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, Tampa, Florida 33612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burt E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Basic Biomedical Science, College of Medicine, University of South Florida, Tampa, Florida 33612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12613748"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.203"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(03)00006-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.5088-5097.2001"},{"key":"e_1_3_2_6_2","first-page":"2104","volume":"6","year":"2000","unstructured":"Inoue, K., J. 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