{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:08:52Z","timestamp":1791148132119,"version":"4.1.0"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Borrelia burgdorferi<\/jats:italic>preferentially induces selected genes in mice or ticks, and studies suggest that<jats:italic>ospD<\/jats:italic>is down-regulated in response to host-specific signals. We now directly show that<jats:italic>ospD<\/jats:italic>expression is generally elevated within<jats:italic>Ixodes scapularis<\/jats:italic>compared with mice. We then assessed the importance of OspD throughout the spirochete life cycle by generating OspD-deficient<jats:italic>B. burgdorferi<\/jats:italic>and examining the mutant in the murine model of tick-transmitted Lyme borreliosis. The lack of OspD did not influence<jats:italic>B. burgdorferi<\/jats:italic>infectivity in mice or the acquisition of spirochetes by<jats:italic>I. scapularis<\/jats:italic>. OspD adhered to tick gut extracts in vitro, and the OspD-deficient<jats:italic>B. burgdorferi<\/jats:italic>strain had a threefold decrease in colonization of the tick gut in vivo. This decrease, however, did not alter subsequent spirochete transmission during a second blood meal. These data suggest that<jats:italic>B. burgdorferi<\/jats:italic>can compensate for the lack of OspD in both ticks and mice and that OspD may have a nonessential, secondary, role in<jats:italic>B. burgdorferi<\/jats:italic>persistence within<jats:italic>I. scapularis<\/jats:italic>.<\/jats:p>","DOI":"10.1128\/iai.00632-07","type":"journal-article","created":{"date-parts":[[2007,7,10]],"date-time":"2007-07-10T00:39:11Z","timestamp":1184027951000},"page":"4237-4244","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Role of Outer Surface Protein D in the<i>Borrelia burgdorferi<\/i>Life Cycle"],"prefix":"10.1128","volume":"75","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Sections of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Neelakanta","sequence":"additional","affiliation":[{"name":"Sections of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Sections of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah S.","family":"Beck","sequence":"additional","affiliation":[{"name":"Sections of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred S.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Allergy and Immunology, Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durland","family":"Fish","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8031"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Entomology, Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504-1106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[{"name":"Sections of Rheumatology"},{"name":"Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8031"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.1.133"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.9.2445-2452.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3371-3383.2003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7043737"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01698.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1755-1759.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306845101"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2954-2957.2001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.446-455.2001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02035-05"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1365-2958.2006.05550.x","volume":"63","year":"2007","unstructured":"Li, X., U. 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