{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:08:13Z","timestamp":1790489293154,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Intradermal infection of methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MRSA) in burned mice was pathogenically analyzed. An abscess was formed in normal mice intradermally infected with 10\n            <jats:sup>8<\/jats:sup>\n            CFU\/mouse of MRSA, and all of these mice survived after the infection; however, abscess formation was not demonstrated to occur in burned mice similarly exposed to the pathogen, and all of these mice died within 5 days of infection. In burned mice, MRSA infected at the burn site intradermal tissues spread quickly throughout the whole body, while in normal mice, the pathogen remained localized at the infection site. Macrophages (M\u03c6) isolated from the infection site tissues of normal mice produced interleukin-12 (IL-12) but not IL-10 and were characterized as M1M\u03c6. These M1M\u03c6 were not isolated from the infection site tissues of burned mice. When normal-mouse infection site tissue M\u03c6 were adoptively transferred to burned mice at the MRSA infection site, an abscess formed, and the infection did not develop into sepsis. In contrast, an abscess did not form and sepsis developed in normal mice that were inoculated with burned-mouse infection site tissue M\u03c6. These M\u03c6 produced IL-10 but not IL-12 and were characterized as M2M\u03c6. These results indicate that abscess formation is a major mechanism of host resistance against intradermal MRSA infection. M1M\u03c6 in the tissues surrounding the infection site play a pivotal role in abscess formation; however, the abscess is not formed in burned mice where M2M\u03c6 predominate. M2M\u03c6 have been described as inhibitor cells for M\u03c6 conversion from resident M\u03c6 to M1M\u03c6.\n          <\/jats:p>","DOI":"10.1128\/iai.00642-10","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T02:16:02Z","timestamp":1280801762000},"page":"4311-4319","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Pathogenic Role of Macrophages in Intradermal Infection of Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            in Thermally Injured Mice"],"prefix":"10.1128","volume":"78","author":[{"given":"Akira","family":"Asai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas"},{"name":"Shriners Hospitals for Children, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Hanafusa","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Osaka Medical College Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Herndon","sequence":"additional","affiliation":[{"name":"Shriners Hospitals for Children, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas"},{"name":"Shriners Hospitals for Children, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"389","volume":"109","year":"1987","unstructured":"Bamberger, D., K. 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