{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:15:06Z","timestamp":1790406906494,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    targets and enters epithelial cells at permissive entry sites: some cells are more likely to be infected than others. However, the parameters that lead to host cell heterogeneity are not known. Here, we quantitatively characterized host cell vulnerability to\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    infection based on imaged parameters. We performed successive infections of the same host cell population followed by automated high-throughput microscopy and observed that infected cells have a higher probability of being reinfected. Establishing a predictive model, we identified two combined origins of host cell vulnerability: pathogen-induced cellular vulnerability emerging from\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    uptake and persisting at later stages of the infection and host cell-inherent vulnerability. We linked the host cell-inherent vulnerability with its morphological attributes, such as local cell crowding, and with host cell cholesterol content. This showed that the probability of\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    infection success can be forecast from morphological or molecular host cell parameters.\n                  <\/jats:p>","DOI":"10.1128\/iai.00644-17","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T11:15:23Z","timestamp":1509362123000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Identification of Parameters of Host Cell Vulnerability during Salmonella Infection by Quantitative Image Analysis and Modeling"],"prefix":"10.1128","volume":"86","author":[{"given":"Jakub","family":"Voznica","sequence":"first","affiliation":[{"name":"Institut Pasteur, Dynamics of Host-Pathogen Interactions Unit, Paris, France"},{"name":"Institut Pasteur, BioImage Analysis Unit, Paris, France"},{"name":"Ecole Normale Sup\u00e9rieure de Cachan, Universit\u00e9 Paris-Saclay, Cachan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Gardella","sequence":"additional","affiliation":[{"name":"Laboratoire de Physique Statistique, CNRS, UPMC and Ecole Normale Sup\u00e9rieure, Paris, France"},{"name":"Institut de la Vision, INSERM, UPMC, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilia","family":"Belotserkovsky","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Molecular Microbial Pathogenesis Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Dufour","sequence":"additional","affiliation":[{"name":"Institut Pasteur, BioImage Analysis Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost","family":"Enninga","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Dynamics of Host-Pathogen Interactions Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-4085","authenticated-orcid":false,"given":"Virginie","family":"St\u00e9venin","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Dynamics of Host-Pathogen Interactions Unit, Paris, 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