{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:08:30Z","timestamp":1789178910438,"version":"build-2803163510"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Mammalian hosts often develop distinct immune response against the diverse parasitic helminths that have evolved for immune evasion. Interleukin-25 (IL-25), an IL-17 cytokine family member, plays a key role in initiating the protective immunity against several parasitic helminths; however, the involvement and underlying mechanisms by which IL-25 mediates immune response against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Trichinella spiralis<\/jats:named-content>\n            infection have not been investigated. Here we showed that IL-25 functions in promoting protective immunity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            infection. Mice treated with IL-25 exhibited a lower worm burden and fewer muscle larvae in the later stage of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            infection. In contrast, mice treated with neutralizing antibody against IL-25 failed to expel\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            effectively. During\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            infection, intestinal IL-25 expression was rapidly elevated before the onset of IL-4 and IL-9 induction. While antigen-specific Th2 and Th9 immune responses were both developed during\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            infection, an antigen-specific Th9 response appeared to be transiently induced in the early stage of infection. Mice into which antigen-specific T cells deficient in IL-9 were transferred were less effective in worm clearance than those given wild-type T cells. The strength of the antigen-specific Th9 immune response against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            could be enhanced or attenuated after treatment with IL-25 or neutralizing antibody against IL-25, respectively, correlating positively with the levels of intestinal mastocytosis and the expression of IL-9-regulated genes, including mast cell- and Paneth cell-specific genes. Thus, our study demonstrates that intestinal IL-25 promotes protective immunity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. spiralis<\/jats:named-content>\n            infection by inducing antigen-specific Th9 immune response.\n          <\/jats:p>","DOI":"10.1128\/iai.00646-13","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T03:01:12Z","timestamp":1375153272000},"page":"3731-3741","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Interleukin-25 (IL-25) Promotes Efficient Protective Immunity against Trichinella spiralis Infection by Enhancing the Antigen-Specific IL-9 Response"],"prefix":"10.1128","volume":"81","author":[{"given":"Pornpimon","family":"Angkasekwinai","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Potjanee","family":"Srimanote","sequence":"additional","affiliation":[{"name":"Graduate Program, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui-Hsi","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anek","family":"Pootong","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwaporn","family":"Sakolvaree","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kovit","family":"Pattanapanyasat","sequence":"additional","affiliation":[{"name":"Center of Excellence for Flow Cytometry, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpen","family":"Chaicumpa","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sansanee","family":"Chaiyaroj","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.505"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.08.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(98)00087-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061675"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070406"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051496"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051615"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000450"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.8.3832-3840.1998"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801941"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231488100"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1849"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.41.1.445-447.1983"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1659"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1677"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940281"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021695"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1846"},{"key":"e_1_3_3_22_2","first-page":"73","article-title":"Trichinellosis in Thailand: epidemiology and biochemical identification of the aethiological agent","volume":"40","author":"Pozio E","year":"1989","unstructured":"PozioEKhamboonruangC. 1989. Trichinellosis in Thailand: epidemiology and biochemical identification of the aethiological agent. Trop. Med. Parasitol. 40:73\u201374.","journal-title":"Trop. Med. Parasitol."},{"key":"e_1_3_3_23_2","first-page":"37","article-title":"Trichinella spiralis-specific monoclonal antibodies and affinity-purified antigen-based diagnosis","volume":"18","author":"Srimanote P","year":"2000","unstructured":"SrimanotePIttiprasertWSermsartBChaisriUMahannopPSakolvareeYTapchaisriPMaleewongWKurazonoHHayashiHChaicumpaW. 2000. Trichinella spiralis-specific monoclonal antibodies and affinity-purified antigen-based diagnosis. Asian Pac. J. Allergy Immunol. 18:37\u201345.","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2553"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102389"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-009-0418-4"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001676"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2133"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2430-2438.2003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41933-8"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01589.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00270.x"}],"container-title":["Infection and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00646-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/IAI.00646-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:15:38Z","timestamp":1646482538000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/IAI.00646-13"}},"subtitle":[],"editor":[{"suffix":"Jr.","given":"J. F.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1128\/IAI.00646-13"],"URL":"https:\/\/doi.org\/10.1128\/iai.00646-13","relation":{},"ISSN":["0019-9567","1098-5522"],"issn-type":[{"value":"0019-9567","type":"print"},{"value":"1098-5522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"2013-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}