{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:15:05Z","timestamp":1694636105978},"reference-count":38,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Trypanosoma congolense<\/jats:italic>\n            is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL),\n            <jats:italic>Tir1<\/jats:italic>\n            ,\n            <jats:italic>Tir2<\/jats:italic>\n            , and\n            <jats:italic>Tir3<\/jats:italic>\n            , control the survival time of mice after infection with\n            <jats:italic>T. congolense<\/jats:italic>\n            . Congenic mice carrying the C57BL\/6 resistance alleles on the A\/J background were developed for each of these loci. The congenic mice were used to physically map the regions containing the QTL gene(s) and to investigate the physiological effect of each locus. Clinical chemistry data for infected A\/J, C57BL\/6, and BALB\/c mice were obtained for 15 analytes at five time points. Congenic mice were assessed for survival, parasitemia, and anemia as well as seven clinical-chemical analytes. The survival times were significantly increased in the\n            <jats:italic>Tir1<\/jats:italic>\n            and\n            <jats:italic>Tir2<\/jats:italic>\n            mice but not\n            <jats:italic>Tir3<\/jats:italic>\n            congenic mice. The survival time of the parental inbred mice correlated negatively with parasitemia but positively with alanine aminotransferase activities in serum, suggesting that inflammatory reactions in the liver had a beneficial effect possibly associated with reduced parasitemia. However, there was no difference in parasitemia or liver enzyme activities of\n            <jats:italic>Tir1<\/jats:italic>\n            and\n            <jats:italic>Tir2<\/jats:italic>\n            congenic mice relative to their controls, showing that survival, parasitemia, and degree of liver damage are not associated with each other, despite the correlation in the parental lines. These data suggest that the congenic loci affect survival but do not affect control of parasite number. They may therefore act by limiting the pathological consequences of\n            <jats:italic>T. congolense<\/jats:italic>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/iai.00658-09","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:54:13Z","timestamp":1247532853000},"page":"3948-3957","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to\n            <i>Trypanosoma congolense<\/i>\n            Infection"],"prefix":"10.1128","volume":"77","author":[{"given":"Birgit","family":"Rathkolb","sequence":"first","affiliation":[{"name":"Institute of Experimental Genetics, Helmholtz Zentrum Mu\u0308nchen, Ingolsta\u0308dter Landstra\u00dfe 1, D-85764 Neuherberg, Germany"},{"name":"Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig Maximilians Universita\u0308t Mu\u0308nchen, Feodor-Lynen-Str. 25, D-81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry A.","family":"Noyes","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Brass","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom"},{"name":"School of Computer Science, Kilburn Building, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Dark","sequence":"additional","affiliation":[{"name":"Intensive Care Medicine, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester M6 8HD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics, Helmholtz Zentrum Mu\u0308nchen, Ingolsta\u0308dter Landstra\u00dfe 1, D-85764 Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vale\u0301rie","family":"Gailus-Durner","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics, Helmholtz Zentrum Mu\u0308nchen, Ingolsta\u0308dter Landstra\u00dfe 1, D-85764 Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gibson","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Hrabe\u0301","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Institute of Experimental Genetics, Helmholtz Zentrum Mu\u0308nchen, Ingolsta\u0308dter Landstra\u00dfe 1, D-85764 Neuherberg, Germany"},{"name":"Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technische Universita\u0308t Mu\u0308nchen, Alte Akademie 8, D 85354 Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Ogugo","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad","family":"Iraqi","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve J.","family":"Kemp","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya"},{"name":"School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Naessens","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. Box 30709, Nairobi 00100, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew E.","family":"Pope","sequence":"additional","affiliation":[{"name":"International Livestock Research Institute, P.O. 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