{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:08:48Z","timestamp":1791058128160,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Bartonella quintana<\/jats:italic>\n                    causes trench fever, endocarditis, and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis in humans. Little is known about the interaction of this pathogen with host cells. We attempted to elucidate the interaction of\n                    <jats:italic>B. quintana<\/jats:italic>\n                    with human macrophages (THP-1) and epithelial cells (HeLa 229). Remarkably, only\n                    <jats:italic>B. quintana<\/jats:italic>\n                    strain JK-31 induced secretion of vascular endothelial growth factor (VEGF) from THP-1 and HeLa 229 cells upon infection similar to the secretion induced by\n                    <jats:italic>B. henselae<\/jats:italic>\n                    Marseille, whereas other strains (\n                    <jats:italic>B. quintana<\/jats:italic>\n                    2-D70,\n                    <jats:italic>B. quintana<\/jats:italic>\n                    Toulouse, and\n                    <jats:italic>B. quintana<\/jats:italic>\n                    Munich) did not induce such secretion. Immunofluorescence testing and electron microscopy revealed that the\n                    <jats:italic>B. quintana<\/jats:italic>\n                    strains unable to induce VEGF secretion did not express the variable outer membrane proteins (Vomps) on their surfaces. Surprisingly, the increase in VEGF secretion mediated by\n                    <jats:italic>B. quintana<\/jats:italic>\n                    JK-31 was not paralleled by elevated host cell adherence rates compared with the rates for Vomp-negative\n                    <jats:italic>B. quintana<\/jats:italic>\n                    strains. Our results suggest that the Vomps play a leading role in the angiogenic reprogramming of host cells by\n                    <jats:italic>B. quintana<\/jats:italic>\n                    but not in the adherence to host cells.\n                  <\/jats:p>","DOI":"10.1128\/iai.00663-06","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T18:13:07Z","timestamp":1156270387000},"page":"5003-5013","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["<i>Bartonella quintana<\/i>\n                    Variably Expressed Outer Membrane Proteins Mediate Vascular\u2009Endothelial\u2009Growth\u2009Factor\u2009Secretion\u2009but\u2009Not\u2009Host\u2009Cell\u2009Adherence"],"prefix":"10.1128","volume":"74","author":[{"given":"Berit","family":"Schulte","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universita\u0308t, Elfriede-Aulhorn-Str. 6, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Linke","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Entwicklungsbiologie, Abteilung Proteinevolution, Spemannstr. 35, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Klumpp","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universita\u0308t, Elfriede-Aulhorn-Str. 6, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schaller","sequence":"additional","affiliation":[{"name":"Universita\u0308ts-Hautklinik, Eberhard-Karls-Universita\u0308t, Liebermeisterstra\u00dfe 25, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Riess","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universita\u0308t, Elfriede-Aulhorn-Str. 6, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo B.","family":"Autenrieth","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universita\u0308t, Elfriede-Aulhorn-Str. 6, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkhard A. 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