{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:04:38Z","timestamp":1791097478101,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>While CD8<jats:sup>+<\/jats:sup>cells have been shown to contribute to lung injury during<jats:italic>Pneumocystis carinii<\/jats:italic>pneumonia (PCP), there are conflicting reports concerning the ability of CD8<jats:sup>+<\/jats:sup>cells to kill<jats:italic>P. carinii.<\/jats:italic>To address these two issues, we studied the effect of the presence of CD8<jats:sup>+<\/jats:sup>cells in two mouse models of PCP. In the reconstituted SCID mouse model, depletion of CD8<jats:sup>+<\/jats:sup>cells in addition to CD4<jats:sup>+<\/jats:sup>cells after reconstitution did not result in increased numbers of<jats:italic>P. carinii<\/jats:italic>cysts compared to the numbers of cysts in mice with only CD4<jats:sup>+<\/jats:sup>cells depleted. This result was observed regardless of whether the mice were reconstituted with nai\u0308ve or<jats:italic>P. carinii<\/jats:italic>-sensitized lymphocytes. In contrast, reconstitution with sensitized lymphocytes resulted in more rapid onset of lung injury that was dependent on the presence of CD8<jats:sup>+<\/jats:sup>cells. The course of organism replication over a 6-week period was also examined in the CD4<jats:sup>+<\/jats:sup>-T-cell-depleted and CD4<jats:sup>+<\/jats:sup>- and CD8<jats:sup>+<\/jats:sup>-T-cell-depleted mouse model of PCP. Again, the organism burdens were identical at all times regardless of whether CD8<jats:sup>+<\/jats:sup>cells were present. Thus, in the absence of CD4<jats:sup>+<\/jats:sup>T cells, CD8<jats:sup>+<\/jats:sup>T cells are a key contributor to the inflammatory lung injury associated with PCP. However, we were unable to demonstrate an in vivo effect of these cells on the course of<jats:italic>P. carinii<\/jats:italic>infection.<\/jats:p>","DOI":"10.1128\/iai.00668-06","type":"journal-article","created":{"date-parts":[[2006,10,20]],"date-time":"2006-10-20T22:57:47Z","timestamp":1161385067000},"page":"6310-6316","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Sensitized CD8<sup>+<\/sup>T Cells Fail To Control Organism Burden but Accelerate the Onset of Lung Injury during<i>Pneumocystis carinii<\/i>Pneumonia"],"prefix":"10.1128","volume":"74","author":[{"given":"Francis","family":"Gigliotti","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott L.","family":"Crow","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir P.","family":"Bhagwat","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry W.","family":"Wright","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics"},{"name":"Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1958.192.2.364"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(96)90044-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000194692"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00533-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.97-102.1993"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.11.6211-6220.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/514128"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050075"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.3.937"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.4049\/jimmunol.162.5.2890","volume":"162","year":"1999","unstructured":"Kolls, J. K., S. Habetz, M. K. Shean, C. Vazquez, J. A. Brown, D. Lei, P. Schwarzenberger, P. Ye, S. Nelson, W. R. Summer, and J. E. Shellito. 1999. IFN-gamma and CD8+ T cells restore host defenses against Pneumocystis carinii in mice depleted of CD4+ T cells. J. Immunol.162:2890-2894.","journal-title":"J. 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