{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:56:50Z","timestamp":1789617410268,"version":"build-2803163510"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["IC18-CT980373"],"award-info":[{"award-number":["IC18-CT980373"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017923","name":"French Parasitology Alliance for Health Care","doi-asserted-by":"crossref","award":["ANR-11-LABX-0024-01"],"award-info":[{"award-number":["ANR-11-LABX-0024-01"]}],"id":[{"id":"10.13039\/100017923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council UK","doi-asserted-by":"crossref","award":["U117585869"],"award-info":[{"award-number":["U117585869"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The College of Medicine at the University of Ibadan"},{"name":"The Childhood Malaria Research Group of Ibadan"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cerebral malaria (CM) is a neurological complication of infection with\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            that is partly caused by cytokine-mediated inflammation. It is not known whether interleukin-17 (IL-17) cytokines, which regulate inflammation, control the development of CM. To evaluate the involvement of IL-17 cytokines in CM, we analyzed 46 common polymorphisms in\n            <jats:italic>IL17A<\/jats:italic>\n            ,\n            <jats:italic>IL17F<\/jats:italic>\n            , and\n            <jats:italic>IL17RA<\/jats:italic>\n            (which encodes the common receptor chain of the members of the IL-17 family) in two independent African populations. A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that\n            <jats:italic>IL17F<\/jats:italic>\n            reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (\n            <jats:italic>P<\/jats:italic>\n            = 0.004; odds ratio [OR] = 3.12),\n            <jats:italic>IL17F<\/jats:italic>\n            rs4715291 (\n            <jats:italic>P<\/jats:italic>\n            = 0.004; OR = 2.82),\n            <jats:italic>IL17RA<\/jats:italic>\n            rs12159217 (\n            <jats:italic>P<\/jats:italic>\n            = 0.01; OR = 2.27), and\n            <jats:italic>IL17RA<\/jats:italic>\n            rs41396547 (\n            <jats:italic>P<\/jats:italic>\n            = 0.026; OR = 3.15) were independently associated with CM. A replication study was performed in 240 nuclear Malian family trios (two parents with one CM child). We replicated the association for 3 SNPs,\n            <jats:italic>IL17F<\/jats:italic>\n            rs6913472 (\n            <jats:italic>P<\/jats:italic>\n            = 0.03; OR = 1.39),\n            <jats:italic>IL17RA<\/jats:italic>\n            rs12159217 (\n            <jats:italic>P<\/jats:italic>\n            = 0.01; OR = 1.52), and\n            <jats:italic>IL17RA<\/jats:italic>\n            rs41396547 (\n            <jats:italic>P<\/jats:italic>\n            = 0.04; OR = 3.50). We also found that one additional SNP,\n            <jats:italic>IL17RA<\/jats:italic>\n            rs41433045, in linkage disequilibrium (LD) with rs41396547, was associated with CM in both Nigeria and Mali (\n            <jats:italic>P<\/jats:italic>\n            = 0.002; OR = 4.12 in the combined sample). We excluded the possibility that SNPs outside\n            <jats:italic>IL17F<\/jats:italic>\n            and\n            <jats:italic>IL17RA<\/jats:italic>\n            , in strong LD with the associated SNPs, could account for the observed associations. Furthermore, the results of a functional study indicated that the aggravating GA genotype of\n            <jats:italic>IL17F<\/jats:italic>\n            rs6913472 was associated with lower IL-17F concentrations. Our findings show for the first time that\n            <jats:italic>IL17F<\/jats:italic>\n            and\n            <jats:italic>IL17RA<\/jats:italic>\n            polymorphisms modulate susceptibility to CM and provide evidence that IL-17F protects against CM.\n          <\/jats:p>","DOI":"10.1128\/iai.00671-15","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T04:24:41Z","timestamp":1450153481000},"page":"590-597","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["The\n            <i>IL17F<\/i>\n            and\n            <i>IL17RA<\/i>\n            Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations"],"prefix":"10.1128","volume":"84","author":[{"given":"Sandrine","family":"Marquet","sequence":"first","affiliation":[{"name":"Aix-Marseille Universit\u00e9, UMR_S 906, Marseille, France"},{"name":"Inserm, U906, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ianina","family":"Conte","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, Mill Hill Laboratory, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belco","family":"Poudiougou","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Department of Epidemiology of Parasitic Disease, Faculty of Medicine, USTTB, Bamako, Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Argiro","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, UMR_S 906, Marseille, France"},{"name":"Inserm, U906, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Cabantous","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, UMR_S 906, Marseille, France"},{"name":"Inserm, U906, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lia","family":"Dessein","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, UMR_S 906, Marseille, France"},{"name":"Inserm, U906, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Burt\u00e9","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, Mill Hill Laboratory, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacar A.","family":"Oumar","sequence":"additional","affiliation":[{"name":"Centre des Oeuvres Universitaires, University of Bamako, Bamako, Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biobele J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoualye","family":"Traore","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Department of Epidemiology of Parasitic Disease, Faculty of Medicine, USTTB, Bamako, Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel K.","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye","family":"Barry","sequence":"additional","affiliation":[{"name":"Paediatric Wards, Gabriel Toure Hospital, Bamako, Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Omokhodion","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursule Ewanda","family":"Ndoumbe","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, UMR_S 906, Marseille, France"},{"name":"Inserm, U906, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuraola A.","family":"Shokunbi","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbemiro","family":"Sodeinde","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute, Mill Hill Laboratory, London, United Kingdom"},{"name":"Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Department of Haematology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Childhood Malaria Research Group, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria"},{"name":"Department of Computer Science, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogobara","family":"Doumbo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, Department of Epidemiology of Parasitic Disease, Faculty of Medicine, USTTB, 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