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Previously we showed that infection with the rat tapeworm,\n            <jats:named-content content-type=\"genus-species\">Hymenolepis diminuta<\/jats:named-content>\n            , used as a model helminth, or systemic delivery of worm antigen (HdAg) significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Extending these analyses, intraperitoneal injection of HdAg dose-dependently suppressed dextran sodium sulfate (DSS)-induced colitis, and this was paralleled by reduced gamma interferon (IFN-\u03b3), interleukin-17 (IL-17), and tumor necrosis factor alpha (TNF-\u03b1) production and increased IL-10 production from mitogen-activated splenocytes. Treatment with HdAg resulted in a CCR2-dependent recruitment of CDllb\n            <jats:sup>+<\/jats:sup>\n            F4\/80\n            <jats:sup>+<\/jats:sup>\n            Ly6C\n            <jats:sup>hi<\/jats:sup>\n            Gr-1\n            <jats:sup>lo<\/jats:sup>\n            monocyte-like cells into the peritoneum 24 h later that were predominantly programmed death ligand 1 (PD-L1) positive and CXCR2 negative.\n            <jats:italic>In vitro<\/jats:italic>\n            assays indicated that these cells were unable to suppress T cell proliferation but enhanced IL-10 and IL-4 production from activated T cells. Adoptive transfer of the HdAg-recruited monocytic cells into naive mice blocked DSS-induced colitis. These findings add to the variety of means by which treatment with parasitic helminth-derived antigens can ameliorate concomitant disease. A precise understanding of the mechanism(s) of action of HdAg and other helminth-derived antigens (and a parallel consideration of putative side effects) may lead to the development of novel therapies for human idiopathic disorders such as inflammatory bowel disease.\n          <\/jats:p>","DOI":"10.1128\/iai.00681-16","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T03:14:22Z","timestamp":1474946062000},"page":"3471-3483","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2\n            <sup>+<\/sup>\n            Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis"],"prefix":"10.1128","volume":"84","author":[{"given":"Jos\u00e9 L.","family":"Reyes","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Laboratorio de Immunolog\u00eda Experimental y Regulaci\u00f3n de la Inflamaci\u00f3n Hepato-Intestinal, UBIMED, FES Iztacala, UNAM, Estado de Mexico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Lopes","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Leung","sequence":"additional","affiliation":[{"name":"Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, 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